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REVIEW article

Front. Pediatr.
Sec. Pediatric Neurology
Volume 12 - 2024 | doi: 10.3389/fped.2024.1472982

Ketogenic Diets Therapy in the Management of Epileptic Spasms Syndrome

Provisionally accepted
Meng Wang Meng Wang 1*Fen Zhao Fen Zhao 1Lina Sun Lina Sun 2*Hongwei Zhang Hongwei Zhang 1*Yanyan Yu Yanyan Yu 1*
  • 1 Epilepsy Center, Jinan Children's Hospital, Jinan, China
  • 2 Department of Special Function Examination, Anqiu City People's Hospital, Weifang, Shandong Province, China

The final, formatted version of the article will be published soon.

    Infantile Epileptic Spasm Syndrome (IESS) is a group of infantile spasm syndromes of various etiologies that typically present in early infancy, predispose to refractory epilepsy, and leave intellectual disability. Ketogenic diet therapy (KDT) is a non-pharmacologic treatment modality for medically refractory IESS. Recent scientific evidence supported the efficacy, safety, and tolerability of KDT for the treatment of IESS. KDT not only reduces the frequency of seizures in infants with IESS, but also improve their cognition and long-term prognosis. Recently, it has also received increasing attention as a potential treatment for neurological disorders. This reviewed the recent research progress of KDTs for the treatment of IESS, and discussed the different types and the mechanisms of KDTs, the expansion of KDT applications, the influencing factors, and future research issues.

    Keywords: Ketogenic diet therapy, Infantile Epileptic Spasm Syndrome, refractory epilepsy, mechanisms, Treatment

    Received: 30 Jul 2024; Accepted: 14 Oct 2024.

    Copyright: © 2024 Wang, Zhao, Sun, Zhang and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Meng Wang, Epilepsy Center, Jinan Children's Hospital, Jinan, China
    Lina Sun, Department of Special Function Examination, Anqiu City People's Hospital, Weifang, Shandong Province, China
    Hongwei Zhang, Epilepsy Center, Jinan Children's Hospital, Jinan, China
    Yanyan Yu, Epilepsy Center, Jinan Children's Hospital, Jinan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.