Skip to main content

MINI REVIEW article

Front. Pediatr.
Sec. Neonatology
Volume 12 - 2024 | doi: 10.3389/fped.2024.1432808
This article is part of the Research Topic What is new on the Horizon in Neonatology? Recent Advances in Monitoring, Diagnostics, and Therapeutics in Neonatal Care. View all 17 articles

Understanding Necrotizing Enterocolitis and Acquired Intestinal Injury Phenotypes from a Historical and Artificial Intelligence Perspective

Provisionally accepted
Alain Cuna Alain Cuna 1Navin Kumar Navin Kumar 2Venkatesh Sampath Venkatesh Sampath 1*
  • 1 Children's Mercy Kansas City, Kansas City, United States
  • 2 Hurley Medical Center, Flint, Michigan, United States

The final, formatted version of the article will be published soon.

    Necrotizing enterocolitis (NEC) remains a devastating disease in preterm and term neonates. Despite significant progress made in understanding NEC pathogenesis over the last 50 years, the inability of current definitions to discriminate the various pathophysiological processes underlying NEC has led to an umbrella term that limits clinical and research progress. In this mini review, we provide a historical perspective on how NEC definitions and pathogenesis have evolved to our current understanding of NEC endotypes. We also discuss how artificial intelligence-based approaches are influencing our knowledge of risk-factors, classification and prognosis of NEC and other neonatal intestinal injury phenotypes

    Keywords: Necrotizing entercolitis, machine learning, Phenotype [Mesh], Endotype, prematurity, Neonate .

    Received: 14 May 2024; Accepted: 13 Sep 2024.

    Copyright: © 2024 Cuna, Kumar and Sampath. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Venkatesh Sampath, Children's Mercy Kansas City, Kansas City, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.