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REVIEW article

Front. Pediatr.
Sec. Pediatric Pulmonology
Volume 12 - 2024 | doi: 10.3389/fped.2024.1343870
This article is part of the Research Topic Pediatric Respiratory Critical Illness: Etiology, Diagnosis, and Treatment View all 8 articles

Research progress on pathophysiologic mechanisms, clinical treatment and predictive biomarkers in bronchopulmonary dysplasia: from the perspective of oxidative stress

Provisionally accepted
Min Li Min Li 1Wen-Xiang Cheng Wen-Xiang Cheng 2Shuo Li Shuo Li 3Jing Wang Jing Wang 1Yan-Rui Chen Yan-Rui Chen 1Liang Li Liang Li 4Gui Yang Gui Yang 1*
  • 1 Longgang Central Hospital, Shenzhen, Guangdong Province, China
  • 2 Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences (CAS), Shenzhen, Guangdong Province, China
  • 3 Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, China, shenzhen, China
  • 4 Southern University of Science and Technology, Shenzhen, Guangdong Province, China

The final, formatted version of the article will be published soon.

    With the global rise in preterm birth rates, bronchopulmonary dysplasia (BPD) continues to be a significant problem, affecting morbidity and mortality in surviving preterm infants. Preterm infants are particularly susceptible to oxidative stress induced by sudden increases in oxygen concentration, which plays a crucial role in the pathogenesis of BPD. Herein, we addressed the pathophysiologic mechanisms, clinical treatment, and predictive biomarkers of BPD from an oxidative stress perspective. We first review the importance of oxygen in preterm infants and point out that sustained exposure to hyperoxia exacerbates the susceptibility of the immature lung to free radicals. The antioxidant properties of clinical therapies for BPD in preterm infants are then summarized. Subsequently, based on lipid, protein, and DNA damage mechanisms, we obtained the most comprehensive, accurate, and representative oxidative stress biomarkers. A total of 37 research papers on oxidative stress in BPD were collected. We conclude that 8-OHdG is the most promising biomarker for early prediction of BPD pathogenesis compared to lipid and protein oxidative stress biomarkers.

    Keywords: Bronchopulmonary Dysplasia, Hyperoxia exposure, Oxidative Stress, Antioxidant treatments, predictive biomarkers

    Received: 24 Nov 2023; Accepted: 09 Sep 2024.

    Copyright: © 2024 Li, Cheng, Li, Wang, Chen, Li and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Gui Yang, Longgang Central Hospital, Shenzhen, Guangdong Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.