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Original Research

Published on 22 Apr 2022

Comprehensive Target Screening and Cellular Profiling of the Cancer-Active Compound b-AP15 Indicate Abrogation of Protein Homeostasis and Organelle Dysfunction as the Primary Mechanism of Action

in Pharmacology of Anti-Cancer Drugs

  • Johannes Gubat
  • Karthik Selvaraju
  • Linda Sjöstrand
  • Dhananjay Kumar Singh
  • Maria V. Turkina
  • Bernhard Schmierer
  • Pierre Sabatier
  • Roman A. Zubarev
  • Stig Linder
  • Pádraig D’Arcy
Comprehensive Target Screening and Cellular Profiling of the Cancer-Active Compound b-AP15 Indicate Abrogation of Protein Homeostasis and Organelle Dysfunction as the Primary Mechanism of Action
Frontiers in Oncology
doi 10.3389/fonc.2022.852980
  • 3,927 views
  • 4 citations