ORIGINAL RESEARCH article
Front. Oncol.
Sec. Cancer Molecular Targets and Therapeutics
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1581860
This article is part of the Research TopicAdvancing Biomarker Discovery, Molecular Mechanisms, and Immunological Insights in Tumor Precision MedicineView all articles
Integrated Analysis Identifies P4HA2 as a Key Regulator of STAT1-Mediated Colorectal Cancer Progression and a Potential Biomarker for Precision Therapy
Provisionally accepted
- Second Affiliated Hospital of Dalian Medical University, Dalian, China
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P4HA2 is implicated in regulating the formation of the tumor microenvironment and potentially plays a role in inflammation and tumor immunity. Nevertheless, the underlying mechanism of P4HA2 in colorectal cancer remains largely unexplored. In our study, high P4HA2 expression in CRC tissues was associated with the T stage and M stage of colorectal cancer, which was closely related to the poor prognosis of colorectal cancer patients and was an independent prognostic factor for high risk. The results of the CCK8, wound healing, and Transwell assays confirmed that P4HA2 promoted the proliferation and migration of colorectal cancer cells. Mechanistically, proteomic analysis revealed that P4HA2 regulated the key molecule STAT1, which is 2 involved in the development of colorectal cancer. Additionally, P4HA2 also influenced the expression of molecules in the STAT1/PD-L1 pathway. In conclusion, P4HA2 may affect the STAT1/PD-L1 pathway to promote the development and inhibit the antitumor immunity of colorectal cancer by binding to and downregulating the expression of STAT1, which might reveal a new pathogenic mechanism.
Keywords: ：P4HA2, colorectal cancer, STAT1, prognostic marker, PD-L1
Received: 23 Feb 2025; Accepted: 15 Apr 2025.
Copyright: © 2025 Zhang, Zhang, Sun, Wang, Dai, Meng, Shi and Ren. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shuangyi Ren, Second Affiliated Hospital of Dalian Medical University, Dalian, China
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