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REVIEW article
Front. Oncol.
Sec. Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1523061
This article is part of the Research Topic Advances in Epigenetic Inheritance Regulating Gastrointestinal Cancer View all articles
Circular RNA in Liver Cancer Research: Biogenesis, Functions, and Roles
Provisionally accepted
Jiayi Wang 1*
Congcong Zhang 1
Yinghui Zhang 1 Jiaojiao Guo 1
Chenyu Xie 1 Yulu Liu 2* Yanyu Zhang 3* Liangliang Ma 2*- 1 College of Rehabilitation Medicine, Henan University of Chinese Medicine, Zheng Zhou, China
- 2 Henan University of Chinese Medicine, Zhengzhou, Henan Province, China
- 3 Department of Rehabilitation, First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan Province, China
Liver cancer, characterized by its insidious nature, aggressive invasiveness, and propensity for metastasis, has witnessed a sustained increase in both incidence and mortality rates in recent years, underscoring the urgent need for innovative diagnostic and therapeutic approaches. Emerging research indicates that CircRNAs (circular RNAs) are abundantly and stably present within cells, with their expression levels closely associated with the progression of various malignancies, including hepatocellular carcinoma. In the context of liver cancer progression, circRNAs exhibit promising potential as highly sensitive diagnostic biomarkers, offering novel avenues for early detection, and also function as pivotal regulatory factors within the carcinogenic process. This study endeavors to elucidate the biogenesis, functional roles, and underlying mechanisms of circRNAs in hepatocellular carcinoma, thereby providing a fresh perspective on the pathogenesis of liver cancer and laying a robust foundation for the development of more precise and effective early diagnostic tools and therapeutic strategies.
Keywords: liver cancer, circRNA, diagnostic biomarkers, therapeutic targets, Cancer
Received: 07 Nov 2024; Accepted: 11 Mar 2025.
Copyright: © 2025 Wang, Zhang, Zhang, Guo, Xie, Liu, Zhang and Ma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jiayi Wang, College of Rehabilitation Medicine, Henan University of Chinese Medicine, Zheng Zhou, 450046, China
Yulu Liu, Henan University of Chinese Medicine, Zhengzhou, 450008, Henan Province, China
Yanyu Zhang, Department of Rehabilitation, First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan Province, China
Liangliang Ma, Henan University of Chinese Medicine, Zhengzhou, 450008, Henan Province, China
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