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REVIEW article
Front. Oncol.
Sec. Molecular and Cellular Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1519103
This article is part of the Research Topic Role of nanocarriers and non-coding RNAs in solid malignancies View all 4 articles
Deciphering the Mysteries of MEG3 LncRNA and its Implications in Genitourinary Cancers
Provisionally accepted
Reem Amr Assal 1
Hannah H. Rashwan 2 Zeina I. Zakaria 3 Jana H. Sweillam 4 Yasmine M. Fouda 5 Abdelhamid M. Abdelhamid 2
Rana A. Youness 4*- 1 Faculty of Pharmacy, Heliopolis University, Cairo, Beni Suef, Egypt
- 2 Nile University, Giza, Giza, Egypt
- 3 Ludwig Maximilian University of Munich, Munich, Bavaria, Germany
- 4 German International University, Cairo, Beni Suef, Egypt
- 5 Cairo University, Giza, Giza, Egypt
Maternally expressed gene 3 (MEG3), a long non-coding RNA, plays a pivotal role in various biological processes, including tumorigenesis. Aberrant expression of MEG3 has been implicated in several cancers, including genitourinary malignancies. This comprehensive review explores the multifaceted functions of MEG3 in the context of genitourinary cancers through unravelling the molecular mechanisms underlying the influence of MEG3 on cellular proliferation, apoptosis, invasion, and metastasis. Additionally, we discuss the potential clinical implications of MEG3 as a biomarker and therapeutic target in genitourinary cancers. By unraveling the intricate role of MEG3 in these biological processes, this review aims to contribute to the development of novel strategies for the diagnosis and treatment of genitourinary malignancies.
Keywords: LncRNA - long noncoding RNA, MEG3 lncRNA, Genitourinary cancers, Renal cell carcinma, bladder cacner, prostate cancer, testicular cancer, cervical cancer
Received: 29 Oct 2024; Accepted: 28 Feb 2025.
Copyright: © 2025 Assal, Rashwan, Zakaria, Sweillam, Fouda, Abdelhamid and Youness. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Rana A. Youness, German International University, Cairo, Beni Suef, Egypt
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