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REVIEW article

Front. Oncol.
Sec. Molecular and Cellular Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1481322

Research progress of circRNAs in bone-related diseases

Provisionally accepted
Xianming Hua Xianming Hua 1Lingfeng Yu Lingfeng Yu 2Hao Zhu Hao Zhu 3Yan Zhu Yan Zhu 1Gentao Fan Gentao Fan 1Guangxin Zhou Guangxin Zhou 1,4,5*
  • 1 Department of Orthopedics, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Liaoning Province, China
  • 2 Department of Orthopedic Oncology, Shanghai Bone Tumor Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, PR China., Shanghai, China
  • 3 School of Life Sciences, Nanjing University, Nanjing, Jiangsu Province, China
  • 4 State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing, Jiangsu Province, China
  • 5 Wuxi Xishan NJU Institute of Applied Biotechnology, Wuxi, Jiangsu 214101, China, Wuxi, Liaoning Province, China

The final, formatted version of the article will be published soon.

    Circular RNAs (circRNAs) are non-coding RNAs that exist naturally in various eukaryotic organisms. The majority of circRNAs are produced through the splicing of exons, although there are a limited number that are generated through the circularization of introns. Studies have shown that circRNAs play an irreplaceable role in the pathogenesis, disease progression, diagnosis, and targeted therapy of motor system tumors (osteosarcoma), metabolic diseases (osteoporosis), and degenerative diseases (osteonecrosis of the femoral head, osteoarthritis, intervertebral disc degeneration). This review summarizes the advancements in circRNA detection techniques and the research progress of circRNAs in orthopedic diseases.

    Keywords: CircRNAs, non-coding RNAs, Orthpaedic diseases, Therapeutic target, biomarker

    Received: 06 Sep 2024; Accepted: 10 Jan 2025.

    Copyright: © 2025 Hua, Yu, Zhu, Zhu, Fan and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Guangxin Zhou, Department of Orthopedics, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Liaoning Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.