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REVIEW article
Front. Oncol.
Sec. Pharmacology of Anti-Cancer Drugs
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1490740
Selenium in Cancer Management: Exploring the Therapeutic Potential
Provisionally accepted- 1 Wuhan Polytechnic University, Wuhan, China
- 2 Dongguan Songshan Lake Tungwah Hospital, Dongguan, China
Selenium (Se) is important and plays significant roles in many biological processes or physiological activities. Prolonged selenium deficiency has been conclusively linked to an elevated risk of various diseases, including but not limited to cancer, cardiovascular disease, inflammatory bowel disease, Keshan disease, and acquired immunodeficiency syndrome. The intricate relationship between selenium status and health outcomes is believed to be characterized by a non-linear U-shaped dose-response curve. This review delves into the significance of maintaining optimal selenium levels and the detrimental effects that can arise from selenium deficiency. Of particular interest is the important role that selenium plays in both prevention and treatment of cancer. Finally, this review also explores the diverse classes of selenium entities, encompassing selenoproteins, selenium compounds and selenium nanoparticles, while examining the mechanisms and molecular targets of their anticancer efficacy.
Keywords: Selenium, Cancer, Selenoprotein, Selenium Compounds, selenium nanoparticles;
Received: 03 Sep 2024; Accepted: 16 Dec 2024.
Copyright: © 2024 He, He, Zhang and Peng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhijun He, Wuhan Polytechnic University, Wuhan, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.