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CASE REPORT article
Front. Oncol.
Sec. Neuro-Oncology and Neurosurgical Oncology
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1465676
Primary Intracranial Malignant Melanoma in an Adolescent Girl with NRAS and TP53 Mutations: Case Report and Literature Review
Provisionally accepted- 1 Hebei General Hospital, Shijiazhuang, Hebei Province, China
- 2 Hebei Medical University, Shijiazhuang, Hebei Province, China
Primary intracranial malignant melanoma(PIMM) is often difficult to treat in patients without a history of skin melanoma or extensive melanin deposition. Due to the rarity of the disease, the current accepted treatment is surgical resection, but the prognosis is still poor. We report a case of PIMM in an adolescent girl with epilepsy as the only symptom and atypical imaging findings. PIMM was confirmed by further pathological and clinical examination. We summarize previous cases to discuss the clinical manifestations, imaging, pathological and genetic characteristics of the disease, aiming to improve the clinician's understanding of the disease. This case underscores the PIMM as a differential diagnosis and prompt surgical treatment for adolescents with epileptic seizures accompanied by intracranial space-occupying lesions, even in the absence of extensive skin blackening.
Keywords: case report, Primary malignant melanoma, pediatric, Adolescent, Seizures, Nevus, NRAS
Received: 19 Jul 2024; Accepted: 05 Nov 2024.
Copyright: © 2024 Liu, Shi, Wen, Zhang, 冯, Wei and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hebo Wang, Hebei General Hospital, Shijiazhuang, 050051, Hebei Province, China
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