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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Gynecological Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1445502

Potential Shared Gene Signatures and Molecular Mechanisms Between Recurrent Pregnancy Loss and Ovarian Cancer

Provisionally accepted
Yan Wang Yan Wang 1Yan Cai Yan Cai 1Jiadong Chen Jiadong Chen 1Wenzhe Shen Wenzhe Shen 1Jianqing Zhu Jianqing Zhu 2Qiming Wang Qiming Wang 1*
  • 1 Ningbo Women and Children's Hospital, Ningbo, China
  • 2 Zhejiang Cancer Hospital, hangzhou, China

The final, formatted version of the article will be published soon.

    Ovarian cancer (OV) is the second most prevalent gynecological tumor. Recurrent pregnancy loss (RPL) refers to two or more spontaneous abortions. However, the molecular mechanisms underlying both OV and RPL remain poorly understood. This article focuses on the exploration of the common genetic characteristics of OV and RPL and their molecular mechanisms. The 71 differentially expressed genes associated with RPL and 1427 genes associated with OV survival were analyzed, among which 7 common genes were both important in the pathogenesis of RPL and OV. Then stepAIC analysis was performed to simplify the model and decrease the number of genes, which yielded a final set of 5 prognostic genes with coefficients to construct a prognostic risk scoring system.Univariate and multivariate Cox analyses were conducted to verify the independent prognostic factor for OV patients. GSEA and GO analysis results showed enriched biological pathways in the high/low risk groups, thereby revealing their biological characteristics. The effect of immunotherapy is better in LR patients. There was a significantly higher enrichment score of stemness and higher tumor aneuploidy score in the HR group. A five-gene prognostic risk model provided a more accurate prognosis for OV, and this prognostic score system was validated using two external cohorts. The risk score was an independent prognostic index for OV patients. Based on levels of ICs, immune cell infiltration, and predicted response, low risk OV patients were more likely to benefit from immunotherapies. The 5-gene risk model can predict the prognosis of OV patients, which can draw the attention of clinicians and help stratify patients into high and low risk groups for management.

    Keywords: Common gene, ovarian cancer, Recurrent pregnancy losses, Prognostic risk score system, Immunotherapy

    Received: 07 Jun 2024; Accepted: 29 Oct 2024.

    Copyright: © 2024 Wang, Cai, Chen, Shen, Zhu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Qiming Wang, Ningbo Women and Children's Hospital, Ningbo, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.