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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Molecular and Cellular Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1443303
This article is part of the Research Topic New Insights on Sialic Acid and Sialylated Glycans in the Tumorigenic Process View all 5 articles

Early in vitro Results Indicate that De-O-Acetylated Sialic Acids Increase Selectins Binding in Cancers

Provisionally accepted
Kakali Das Kakali Das 1Megan Kathryn Schulte Megan Kathryn Schulte 1Megan Gerhart Megan Gerhart 1Hala Bayoumi Hala Bayoumi 1Delayna Paulson Delayna Paulson 1Darci M. Fink Darci M. Fink 1Colin Parrish Colin Parrish 2Rachel A Willand-Charnley Rachel A Willand-Charnley 1*
  • 1 South Dakota State University, Brookings, South Dakota, United States
  • 2 Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States

The final, formatted version of the article will be published soon.

    This journal is dedicated to discussing cancer with special emphasis on sialic acid and its various regulatory roles in regulating cancer. Keeping this in mind, we selected this journal because our work focuses on the regulatory effect of sialic acid on cancer. We have demonstrated that a certain modification on sialic acid side chain favors cancer metastasis via Selectins binding. In our manuscript we discuss different types of Selectins molecules which are critical requirements for spreading of cancer cells via metastasis process. Selectins molecules bind to cancer cell to initiate metastasis process. Next , we demonstrate the Selectins molecules and sialic acid on cancer cell surface interact together that trigger signals for initiation of metastasis process. We have shown certain modified form of sialic acid is the critical component to favor Selectins binding on cancer cell surface. Taken together, our work is totally in line with the interest and specialty of this particular journal.

    Keywords: resources, Writing -review & editing. Darci M. Fink: Writing -review & editing. Delayna Paulson: Data curation, Formal analysis, investigation, methodology, Validation, Writing -review & editing. Hala Bayoumi: Data curation, Writing -original draft

    Received: 03 Jun 2024; Accepted: 11 Nov 2024.

    Copyright: © 2024 Das, Schulte, Gerhart, Bayoumi, Paulson, Fink, Parrish and Willand-Charnley. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Rachel A Willand-Charnley, South Dakota State University, Brookings, 57007, South Dakota, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.