ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1591070
This article is part of the Research TopicNatural Products: A Microecological Perspective for Treating Diabetes and its ComplicationsView all articles
Chemical Composition and Nutritional Properties of Gastrodia elata Water Extract and its effects in Rats with Streptozotocin - Induced Diabetic Osteoporosis
Provisionally accepted
- 1Qinba State Key Laboratory of biological resources and ecological environment, Shaanxi University of Technology, Hanzhong, China
- 2Shaanxi University of Science and Technology, Xi'an, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Introduction: Gastrodia elata Blume (G. elata) is an edible medicinal homologous plant with a long history of use. However, to date, there is no evidence of the nutritional components and anti-diabetic and osteoporotic effects of the water extract of G. elata (WGE).In this study, WGE was prepared and analysed for moisture, ash, protein, lipid, mineral, amino acid, total phenolic, and flavonoid content. WGE was analysed using ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS). Furthermore, the effect of WGE on streptozotocin-induced osteoporosis in diabetic rats was explored, along with an in-depth examination of the underlying mechanisms.The results indicated that WGE reduced blood glucose, water, food intake, and body weight and improved hyperglycaemia and organ coefficients. WGE treatment noticeably increased bone mineral density (BMD), repaired bone morphology (BM), restored bone histomorphometric parameters, and ameliorated pathological pancreatic lesions in diabetic rats. It significantly elevated the activity of glutathione (GSH), superoxide dismutase (SOD), and catalase in liver tissues, osteoblast numbers, and the mRNA and protein expression of osteoprotegerin (OPG) and runt-related transcription factor 2 (Runx2). WGE treatment reduced serum inflammatory cytokine levels and the number of osteoclasts and bone marrow adipocytes.The protective effect of WGE against diabetic osteoporosis arises from several mechanisms: lowering blood glucose levels, inhibiting oxidative stress and inflammation, and modulating OPG/ receptor activator of nuclear factor-κB ligand (RANKL) expression. Our results indicated that WGE could serve as a theoretical foundation for the treatment of diabetic osteoporosis.
Keywords: Gastrodia elata Blume, Diabetes Mellitus, Osteoporosis, water extract of Gastrodia elata, osteoblast, osteoclast
Received: 10 Mar 2025; Accepted: 22 Apr 2025.
Copyright: © 2025 Jia, Kang, Li, Yiheng, Gao and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chen Chen, Shaanxi University of Science and Technology, Xi'an, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.