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ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition and Microbes
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1587240
Association between Dietary Index for Gut Microbiota and female infertility: a cross-sectional NHANES 2013--2020
Provisionally accepted- Department of Cardiovascular Diseases, The First Hospital of Jilin University, Changchun 130021, China., Changchun, Hebei Province, China
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The relationship between the gut microbiota and infertility has garnered increasing attention. However, the associations between Dietary Index for Gut Microbiota (DI-GM), an indicator of microbial diversity, and infertility remain insufficiently explored.We analyzed data from 3,058 participants in the NHANES 2013-2020 cycles, employing weighted generalized linear models and smooth curve analyses to examine their associations. Mediation analysis was conducted to assess the role of body mass index (BMI).Results: After adjusting for confounding factors, a higher DI-GM score was significantly associated with a lower prevalence of infertility (OR = 0.89, 95% CI = 0.81-0.98, p = 0.029). Compared with individuals with a DI-GM score of 0-3, those with a score ≥6 presented a significantly lower prevalence of infertility (OR = 0.64, 95% CI = 0.43-0.96, p = 0.039). BMI mediated 5.98% of the association between DI-GM and infertility.A higher DI-GM score is associated with a lower prevalence of infertility.Future studies should employ longitudinal designs to validate these findings.
Keywords: Dietary Index for Gut Microbiota, Infertility, Body Mass Index, Mediation analysis, NHANES
Received: 04 Mar 2025; Accepted: 08 Apr 2025.
Copyright: © 2025 FU, Peng, Cai, Li, Yaoting and Zheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yang Zheng, Department of Cardiovascular Diseases, The First Hospital of Jilin University, Changchun 130021, China., Changchun, Hebei Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.