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ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition and Microbes
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1573249
This article is part of the Research Topic Dietary Modulation of Gut Microbiota-X axis View all 9 articles
A study of correlation of the dietary index for gut microbiota with non-alcoholic fatty liver disease based on 2007-2018 National Health and Nutrition Examination Survey
Provisionally accepted- 1 Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China
- 2 Department of Radiology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China
Objective: To explore the correlation of dietary index for gut microbiota (DI-GM) with nonalcoholic fatty liver disease (NAFLD).Data of 6,711 participants were extracted from the National Health and Nutrition Examination Survey (NHANES) during 2007-2018. A weighted logistic regression analysis was employed for assessment of the correlation of DI-GM with NAFLD, and a restricted cubic spline (RCS) analysis was implemented to examine potential non-linear associations. Subgroup analyses were conducted to identify particularly susceptible groups. Additionally, the synergistic effects of different DI-GM components on NAFLD risk was assessed by weighted quantile sum (WQS) regression.The DI-GM exhibited statistically significant correlation with NAFLD (OR (95%CI):0.91 (0.85,0.98), P=0.015). The results of the RCS analysis indicated a linear correlation of DI-GM and NAFLD (P = 0.810 for non-linearity). Further stratified analyses indicated that the negative correlation of DI-GM with NAFLD were significant and consistent for all subgroups. The results of WQS regression revealed that soybean (27%), refined grains (17%), coffee (16%), and red meat (9%) had the highest contribution weights to NAFLD.As an important tool for assessment of the influences of diet on gut microbiota, DI-GM is negatively correlated with NAFLD risk factors. Soybean, refined grains, coffee, and red meat are key factors influencing NAFLD. The direct correlation of DI-GM with NAFLD shall be explored and the effectiveness of prevention and treatment of NAFLD shall be evaluated by improving DI-GM scores via dietary interventions.
Keywords: Dietary Index for Gut Microbiota, nonalcoholic fatty liver disease, Cross-sectional study, National Health and Nutrition Examination Survey, Gut Microbiota, dietary
Received: 08 Feb 2025; Accepted: 27 Mar 2025.
Copyright: © 2025 Wang, Zhang, Feng, Cao and Fei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiaoliang Fei, Department of Radiology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China
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