ORIGINAL RESEARCH article
Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1563768
Assessment of Thiamine Status and its Association with Clinical Parameters in Patients Undergoing Maintenance Hemodialysis
Provisionally accepted
- 1Internal Medicine III (Nephrology), Naval Medical Center of PLA, Shanghai, China
- 2Shanghai Changzheng Hospital, Huangpu, Shanghai Municipality, China
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Objective: Thiamine deficiency is a common complication in end-stage renal disease (ESRD) patients on maintenance hemodialysis (HD). This cross-sectional study aimed to assess the prevalence of thiamine deficiency and its association with clinical parameters in HD patients.Methods: This study was a single-center cross-sectional study that included 113 maintenance HD patients in our hospital. Thiamine status was evaluated by high-performance liquid chromatography of whole blood samples. We evaluated the association between blood thiamine concentration and other clinical parameters, including markers of iron metabolism and cardiac function.Results: The prevalence of thiamine deficiency was 11.5%. Univariate analysis revealed a significant positive correlation between thiamine levels and iron metabolism markers, including hemoglobin level (Rho = 0.257, p = 0.006), transferrin saturation (Rho = 0.244, p = 0.009), and serum iron (Rho = 0.213, p = 0.025). Multivariate regression analysis confirmed that thiamine levels were independently associated with hemoglobin levels (beta coefficients = 0.25, p = 0.012).Conclusions: These findings suggest an association between lower thiamine levels and anemia in HD patients. Further research is needed to elucidate the underlying mechanisms and to evaluate the efficacy of thiamine supplementation in improving anemia and other clinical outcomes in this population.
Keywords: Thiamine, hemodialysis, Anemia, iron metabolism, Cross-sectional study
Received: 20 Jan 2025; Accepted: 23 Apr 2025.
Copyright: © 2025 Yang, Lan, Zeng, Shao, Ye, Wang, Xue and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Cheng Xue, Shanghai Changzheng Hospital, Huangpu, Shanghai Municipality, China
Nanmei Liu, Internal Medicine III (Nephrology), Naval Medical Center of PLA, Shanghai, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.