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ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutritional Epidemiology
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1561594
Association of serum uric acid-to-high-density lipoprotein cholesterol ratio with cardiovascular disease risk in patients with metabolic dysfunction-associated fatty liver disease: a cross-sectional NHANES analysis
Provisionally accepted- 1 The First Affiliated Hospital of Dali University, Dali, China
- 2 The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China
The relationship between the serum uric acid-to-high-density lipoprotein cholesterol ratio (UHR) and cardiovascular disease(CVD) risk in patients with metabolic dysfunction-associated fatty liver disease (MAFLD).This study aims to investigate the relationship between UHR and cardiovascular disease risk in patients with MAFLD.Methods: Data for this study were obtained from the National Health and Nutrition Examination Survey (NHANES) 2017-2020, in which 3289 patients with MAFLD participated. Participants were grouped according to their ten-year cardiovascular disease risk level, which was assessed by the Framingham Risk Score (FRS). We used binary logistic regression to analyze the relationship between UHR and CVD risk and smoothed curve-fitting models and threshold effect analyses to describe the relationship between UHR and CVD risk scores.After adjusting for all confounders, individuals with high UHR exhibited a higher prevalence of intermediate/high risk by FRS [ odds ratio (OR): 2.12, 95% confidence interval (CI): (1.34, 3.35), P=0.001]. UHR was nonlinear positive correlated with FRS (log-likelihood ratio test <0.001). And there was a breakpoint of 364.38 and an apparent threshold effect. When UHR was lower than 364.38, The FRS increased with increasing UHR (P < 0.0001), whereas when UHR was higher than 364.38, the relationship between FRS and UHR was statistically insignificant (P = 0.0964).The UHR was significantly associated with a ten-year risk of cardiovascular disease in patients with MAFLD.Higher UHR was associated with higher FRS in patients with MAFLD. The UHR can be a valid biomarker for predicting the ten-year risk of cardiovascular disease in patients with MAFLD.
Keywords: Serum uric acid-to-high-density lipoprotein cholesterol ratio (UHR), Metabolic dysfunction-associated fatty liver disease (MAFLD), cardiovascular risk, Framingham risk score (FRS), NHANES
Received: 16 Jan 2025; Accepted: 31 Mar 2025.
Copyright: © 2025 Wang, Shi, Zi, Jun and Shi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Rongjie Shi, The First Affiliated Hospital of Dali University, Dali, China
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