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ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1556527
This article is part of the Research TopicNutraceuticals and Functional Foods in Chronic Disease Prevention and TreatmentView all 8 articles
Unveiling the Therapeutic Benefits of Black Chokeberry (Aronia melanocarpa) in Alleviating Hyperuricemia in Mice
Provisionally accepted- National Chiayi University, Chiayi, Chiayi County, Taiwan
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Background: Hyperuricemia not only increases the risk of cardiovascular diseases such as dyslipidemia, hypertension, coronary artery disease, obesity, metabolic syndrome, and type-2 diabetes, but also severely impacts kidney function, potentially leading to acute kidney injury and chronic kidney disease.Methods: This study aims to investigate the health benefits of black chokeberry (Aronia melanocarpa) on hyperuricemic mice induced by oxonic acid.The experimental results showed that black chokeberry had no significant toxic or negative effects in mice. The Measurement of uric acid (UA) indicated that black chokeberry suppressed the UA levels. Additionally, the xanthine oxidase activity in the high-dose group was significantly decreased, along with reductions in serum urea nitrogen and creatinine levels. Black chokeberry effectively increased the glutathione levels in hyperuricemic mice and reduced malondialdehyde levels, as well as significantly inhibiting adenosine deaminase activity.Its efficacy is comparable to that of the marketed drug allopurinol, underscoring the potential of black chokeberry as a functional product for uric acid reduction.
Keywords: Adenosine Deaminase, Black chokeberry, Hyperuricemia, Uric Acid, Xanthine Oxidase
Received: 07 Jan 2025; Accepted: 14 Apr 2025.
Copyright: © 2025 Liu, Shi and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: She-Ching Wu, National Chiayi University, Chiayi, Chiayi County, Taiwan
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.