ORIGINAL RESEARCH article
Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1555435
This article is part of the Research TopicDiet and Digestive Tract Cancers: Investigating the Nutritional Influences on Gastrointestinal CarcinogenesisView all 8 articles
Association between relative fat mass and colorectal cancer: a crosssectional study
Provisionally accepted
- 1Department of Medical Oncology, The first affiliated hospital of Bengbu medical university, Bengbu, China
- 2Department of Radiation Oncology, The first affiliated hospital of Bengbu medical university, Bengbu, China
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Aims: We aimed to investigate the potential association between relative fat mass (RFM) and colorectal cancer (CRC).Design and methods: Data from the National Health and Nutrition Examination Survey (NHANES) spanning 1999 to 2020 were analyzed. Associations between RFM and CRC were analyzed using multiple logistic regression. Smoothed curve fitting was performed to conduct the association by sex. The stability of associations was assessed using subgroup analyses and interaction tests.Results: Overall, 52,281 participants over the age of 20 years were enrolled. The fully adjusted model observed a positive association between RFM and CRC, with one-unit increases in RFM linked to a 3% greater prevalence of CRC (OR=1.03, 95%CI: 1.01, 1.06). A linear positive association was identified between RFM and CRC in male subjects, while a non-linear relationship was observed in females, with an inflection point at 42. Subgroup analysis revealed that age significantly modified the relationship between RFM and CRC (P for interaction = 0.0085).Conclusion: RFM is strongly associated with CRC prevalence in US adults. Further large-scale prospective investigations are warranted to for verification.
Keywords: Relative fat mass, colorectal cancer, Cross-sectional, NHANES, Obesity
Received: 04 Jan 2025; Accepted: 14 Apr 2025.
Copyright: © 2025 Wang, Song, Zhang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jingjing Zhang, Department of Medical Oncology, The first affiliated hospital of Bengbu medical university, Bengbu, China
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