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SYSTEMATIC REVIEW article
Front. Nutr.
Sec. Nutritional Immunology
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1552358
This article is part of the Research Topic Efficacy of probiotic-enriched foods on digestive health and overall well-being View all 5 articles
The Impact of Probiotics on Oxidative Stress and Inflammatory Markers in Patients with Diabetes: A Meta-Research of Meta-Analysis Studies
Provisionally accepted- 1 The Affiliated Taizhou People's Hospital, Nanjing Medical University, Taizhou, China
- 2 Ningbo Yinzhou District Qianhu Hospital, Ningbo, China
Objective: Probiotic supplementation has gained attention for its potential to modulate inflammatory and oxidative stress biomarkers, particularly in metabolic disorders. This metaanalysis evaluates the effects of probiotics on C-reactive protein (CRP), tumor necrosis factoralpha (TNF-α), interleukin-6 (IL-6), malondialdehyde (MDA), total antioxidant capacity (TAC), glutathione (GSH), and nitric oxide (NO) in patients with diabetes.Methods: A Meta-Research was conducted on 15 meta-analyses of unique 33 randomized controlled trials (RCTs) published between 2015 and 2022, involving 26 to 136 participants aged 26 to 66 years. Data were synthesized using standardized mean differences (SMD), with sensitivity analysis using a random-effect model.Results: Probiotic supplementation significantly reduced CRP (SMD = -0.79, 95% CI: -1.19, -0.38), TNF-α (SMD = -1.35, 95% CI: -2.05, -0.66), and MDA levels (WMD: -0.82, 95% CI: -1.16, -0.47). Probiotics increased GSH (SMD = 1.00, 95% CI: 0.41, 1.59), TAC (SMD = 0.48, 95% CI: 0.27, 0.69), and NO (SMD= 0.60, 95% CI: 0.30, 0.91). Result on IL-6 was not significant (SMD = -0.29, 95% CI: -0.66, 0.09). Sensitivity analyses confirmed robustness.Probiotics significantly improved inflammatory and oxidative stress biomarkers in patients with diabetes, with variations influenced by population and dosage. Future studies should explore novel probiotic strains and longer interventions.
Keywords: Probiotics, Oxidative Stress, Inflammation, metabolic disorders, biomarkers
Received: 27 Dec 2024; Accepted: 28 Jan 2025.
Copyright: © 2025 Chen, Yan, Yang, Xu and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Lv Yang, Ningbo Yinzhou District Qianhu Hospital, Ningbo, China
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