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ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1551987
This article is part of the Research Topic Functional Foods for Metabolic Health View all 16 articles
Flammulina velutipes mycorrhizae dietary fiber attenuates the development of obesity via regulating lipid metabolism in high-fat diet-induced obese mice
Provisionally accepted- 1 Shandong Academy of Agricultural Sciences, Jinan, China
- 2 Shandong Provincial Third Hospital, Jinan, Shandong Province, China
- 3 Institute of Poultry Science, Shandong Academy of Agricultural Sciences, Jinan, Shandong Province, China
Mounting evidence has shown that Flammulina velutipes mycorrhizae dietary fiber (Fv-DF) has the potential to significantly improve health outcomes by addressing lipid metabolic disorders. However, the mechanism underlying Fv-DF in regulating liver lipid metabolism of high-fat diet (HFD)-induced obese mice still merits to be systematically elaborated.Methods: Herein, we conducted a comprehensive study utilizing HFD-induced C57BL/6J mice as an obesity model to investigate the impact of Fv-DF on liver lipid accumulation.The study, which included an evaluation of Fv-DF on a high-fat diet (HFD)induced obese mice, revealed that Fv-DF supplementation can effectively decrease weight gain, improve serum lipid levels, and reduce fat deposition in adipose tissues.The estimation of Fv-DF on liver tissues demonstrated that Fv-DF supplementation significantly ameliorated lipid metabolism and hepatic injury in HFD-induced obese mice. Furthermore, Fv-DF improved lipid metabolism in obese mice by modifying the abundance and related pathways of TG, PC, PE, and other lipid metabolites.Mechanistically, Fv-DF supplementation significantly suppressed the expression of lipid synthesis-related genes while promoting lipid oxidation-related genes.Discussion: Collectively, the findings could inspire significant implications for Fv-DF in developing novel treatments for obesity-related metabolic disorders management.
Keywords: Flammulina velutipes, Dietary Fiber, Obesity, Lipid Metabolism, high-fat diet
Received: 27 Dec 2024; Accepted: 28 Feb 2025.
Copyright: © 2025 Jia, Gao, Zhang, Hou, Shi, Song and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shifa Yang, Institute of Poultry Science, Shandong Academy of Agricultural Sciences, Jinan, 250023, Shandong Province, China
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