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ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutritional Epidemiology
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1551754
This article is part of the Research Topic Objective Dietary Assessment in Nutrition Epidemiology Studies - Volume II View all 20 articles
Relationship between composite dietary antioxidants index and growth indicators in children aged 3-12 years: Results from two observational studies
Provisionally accepted
Rui Wen 1 Huanting Pei 1 Jingyi Ren 1 Siqi Zhu 1 Simeng Qiao 1
Pui Yee Tan 2
Yunyun Gong 2 Min Yang 3
Junsheng Huo 4
Gangqiang Ding 4
Yuxia Ma 5*- 1 Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical University, Hebei Key Laboratory of Environment and Human Health, Shijiazhuang, 050017, China, Shijiazhuang, Hebei Province, China
- 2 School of Food Science and Nutrition, Faculty of Environment, University of Leeds, Leeds, LS2 9JT, UK, Leeds, United Kingdom
- 3 School of Public Health, and Center of Clinical Big Data and Analytics of The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058,China, Hangzhou, Jiangsu Province, China
- 4 National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention，Beijing 100050，China, Beijing, China
- 5 Hebei Medical University, Shijiazhuang, China
Background: The intake of nutrients with antioxidant properties is closely related to numerous health outcomes. However, the evidence regarding the effects of antioxidant nutrient intake on children's growth indicators is still lacking. This study aimed to investigate the relationship between the Composite Dietary Antioxidant Index (CDAI) and child growth indicators in two cohorts. Methods: This study utilized data from 1,064 participants in the Children's Cohort Study on Micronutrient Deficits and Malnutrition (CCSMDM) 2023 database and 2,404 participants from the National Health and Nutrition Examination Survey (NHANES) 2003-2020 database for cross-sectional analyses, with participants aged 3-12 years. The association between CDAI and growth indicators was analyzed using multinomial logistics regression. And we also performed subgroup analyses to determine whether there were differences in gender and explored the dose-response relationship by fitting a restricted cubic spline. Results: After adjusting for potential confounders, CDAI was positively associated with children growth indicators (height: CCSMDM:
Keywords: Dietary antioxidants, Composite Dietary Antioxidant Index, Children growth, Cross-sectional study, Chinese children
Received: 26 Dec 2024; Accepted: 03 Mar 2025.
Copyright: © 2025 Wen, Pei, Ren, Zhu, Qiao, Tan, Gong, Yang, Huo, Ding and Ma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yuxia Ma, Hebei Medical University, Shijiazhuang, China
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