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ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutritional Epidemiology
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1549948
This article is part of the Research Topic Nutrition, Inflammation and Oxidative Stress in Obstetrics and Gynecology View all 10 articles
Association between the Composite Dietary Antioxidant Index and Risk of Endometriosis in Women: A National Population-based Study
Provisionally accepted- 1 Department of Obstetrics and Gynecology, The Fourth Hospital of Harbin Medical University, Harbin, China
- 2 Harbin Medical University, Harbin, Heilongjiang, China
- 3 Harbin Institute of Technology, Harbin, Heilongjiang Province, China
- 4 Jilin Province Jilin Integrated Traditional Chinese and Western Medicine Hospital, Changchun, Hebei Province, China
Background: Composite dietary antioxidant index (CDAI) has been found protective to women's health. However, the association between CDAI level and the risk of endometriosis in women is unclear.Methods: A total of 4153 women from the National Health and Nutrition Examination Survey (NHANES) 2001-2006 were included in this cross-sectional study. We evaluated the association between CDAI level and the risk of endometriosis using three logistic regression models and restricted cubic spline. Stratified and sensitivity analyses were also performed.Results: Logistic regression analysis found that CDAI level was inversely associated with the development of endometriosis. The associated odds ratio (OR) for each SD increase in CDAI was 0.98[95%CI: 0.96-0.99]. After dividing the CDAI level into four quartiles, we found that compared with the CDAI level in Q1(-1.89, -1.79), the ORs[95%CI] associated with endometriosis in Q2(-1.79, -0.69), Q3 (-0.69, 1.42) and Q4(1.42, 47.92) were 0.94[0.87, 1.03], 0.95[0.88, 1.04] and 0.83[0.77, 0.91], respectively, with p trend<0.001. Restricted cubic spline showed a negative dose-response relationship between CDAI level and endometriosis risk. In addition, the protective effect of CDAI on endometriosis was more obvious in women aged 30-39 years (OR=0.
Keywords: Composite Dietary Antioxidant Index, Endometriosis, Women, NHANES, crosssectional 83, 95%CI=0.69-0.99), gave relatively more births (OR=0.82, 95%CI=071-0.93)
Received: 22 Dec 2024; Accepted: 05 Mar 2025.
Copyright: © 2025 Yang, Yu, Sun, Wang and Xing. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yanqi Yang, Department of Obstetrics and Gynecology, The Fourth Hospital of Harbin Medical University, Harbin, China
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