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ORIGINAL RESEARCH article
Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1548796
Factors influencing changes in body composition and nutritional status in patients with hyperacute stroke; Prospective study
Provisionally accepted- Dokkyo Medical University, Mibu, Japan
Background & Aims: Muscle loss not only reduce the effectiveness of the recovery period of rehabilitation after stroke but also prolongs the length of hospital stay. Therefore, it is crucial to maintain muscle mass during the hyperacute phase of stroke. We aimed to investigate the factors that influence changes in muscle mass and quality in patients with hyperacute stroke by using a body composition analyzer.Methods: Body composition assessment was performed on 156 patients admitted to the stroke care unit at the time of admission and 1 week later. Additionally, associations between rehabilitation intervention time, nutritional dosage and administration method, and stroke severity were examined to which factors were affecting body composition.Results: Muscle mass and quality significantly decreased in both men (SMI: 7.41 ± 1.26 to 7.22 ± 1.23 kg/m 2 , p < 0.005, phA: 5.5 ± 1.24 to 5.31 ± 1.29 degree, p < 0.005) and women (SMI: 6.04 ± 1.30 to 5.08 ± 1.20 kg/m2, p < 0.005, phA: 4.58 ± 0.85 to4.18 ± 0.82 degree, p < 0.005)1 week after admission. Rehabilitation intervention time (odds ratio [OR] = 2.12; 95% CI: 1.28-4.47, p = 0.01), and high calorie dosage (OR = 1.53; 95% CI: 1.14-3.21, p = 0.03) significantly reduced the loss of muscle mass. However, stroke severity did not affect variations in body composition.Conclusions: Deterioration in muscle mass and quality was observed during the hyperacute phase of stroke. The risk of muscle mass loss may be reduced with appropriate rehabilitation intervention and diet therapy from the early stage of hospitalization. Therefore, providing early rehabilitation intervention and nutritional management in the hospitalization phase are important to improve treatment effectiveness. In hyperacute stroke treatment, rehabilitation and nutritional administration should be provided as early as possible.
Keywords: Malnutrition, Stroke, Nutritional Support, treatment outcome, Muscles, prognosis
Received: 20 Dec 2024; Accepted: 03 Mar 2025.
Copyright: © 2025 Irisawa, Nakamura, Hirota, Chiba, Hoshiai and Mizushima. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hiroshi Irisawa, Dokkyo Medical University, Mibu, Japan
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