ORIGINAL RESEARCH article
Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1542937
Association Between Visceral Adiposity Index and Osteoarthritis in U.S. Adults Aged 50 and Older: A Cross-Sectional Study
Provisionally accepted
- Department of Orthopedics, Burns and Plastic Surgery The 925th Hospital of People's Liberation Army (PLA) Joint Logistics Support Force, Guiyang, China
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Background: Existing evidence linking visceral adiposity index (VAI) to osteoarthritis (OA) remains limited and requires further investigation. This study aimed to evaluate the potential relationship between higher VAI scores and an increased risk of OA. Methods: A retrospective cross-sectional analysis was conducted using data from 9,464 participants aged 50 and older, sourced from the 2011-2018 National Health and Nutrition Examination Survey (NHANES). The VAI was categorized into three tertiles, with the first tertile (T1) representing the lowest VAI and third tertile (T3) the highest. Weighted logistic regression was employed to examine the association between VAI and OA. To explore potential nonlinear relationships, smoothed curve fitting and threshold effect analyses were performed. Subgroup analyses were performed to validate these findings.The average age of the study population was 63.16 ± 9.05 years, and 47.22% were male. After adjusting for confounding factors, a statistically significant positive correlation was observed between VAI and OA risk (OR = 1.03, 95% CI: 1.01-1.06, P < 0.01). Participants in the highest VAI tertile exhibited a 35% greater likelihood of developing OA compared to those in the lowest tertile (OR = 1.35, 95% CI: 1.06-1.70, P = 0.015). Furthermore, multivariate restricted cubic spline (RCS) regression analysis revealed a nonlinear relationship (nonlinear P < 0.05) with a threshold effect at a VAI value of 3.9. Subgroup analyses showed no significant interaction effects (all P-values for interaction > 0.05). Conclusion: This study highlights a significant association between elevated VAI and an increased risk of developing OA in individuals aged 50 and older. These results emphasize the potential of the VAI as a risk factor for OA and warrant further research to explore its role in prevention and management strategies in older populations.
Keywords: visceral adiposity index, Osteoarthritis, NHANES, Association, Cross-sectional analysis
Received: 16 Dec 2024; Accepted: 23 Apr 2025.
Copyright: © 2025 Wang, Peng, Jiang, Qu and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Fengfu Wu, Department of Orthopedics, Burns and Plastic Surgery The 925th Hospital of People's Liberation Army (PLA) Joint Logistics Support Force, Guiyang, China
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