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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1538766
This article is part of the Research Topic Preventative Medicine: Nutritional and Lifestyle Interventions for Healthy Ageing and Chronic Diseases View all 30 articles

The L-Shaped Association Between Body Roundness Index (BRI) and All-Cause Mortality in Osteoporotic Patients: A Cohort Study Based on NHANES Data

Provisionally accepted
Ziyao Ding Ziyao Ding 1Wenbo Li Wenbo Li 1Haixu Qi Haixu Qi 1Tianci Fang Tianci Fang 2Qirui Zhu Qirui Zhu 1*Xinzhe Qu Xinzhe Qu 1*changchang Chen changchang Chen 1*Jun Sun Jun Sun 3*Yong Pang Yong Pang 3*
  • 1 Xuzhou Medical University, Xuzhou, China
  • 2 The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
  • 3 The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province, China

The final, formatted version of the article will be published soon.

    Abstract Purpose: This study aims to investigate the relationship between the Body Roundness Index (BRI) and overall mortality rates in individuals with osteoporosis (OP), utilizing information sourced from the NHANES database, in order to assess BRI's capability as an indicator for predicting mortality risk. Methods: Data from NHANES (2005 to 2010, 2013-2014, and 2017-2018) were analyzed, including 1,596 osteoporotic individuals aged 50 and above. BRI was calculated based on waist circumference (WC) and height, categorizing participants into high (> 4.07) and low (≤ 4.07) BRI groups. To analyze the relationship between BRI and mortality while accounting for important covariates, we employed weighted Cox proportional hazards models, conducted Kaplan-Meier survival analyses, and utilized restricted cubic splines (RCS). Results: Higher BRI was significantly associated with better long-term survival, showing an "L"-shaped nonlinear inverse relationship with mortality, with a threshold at BRI=5. In subgroup analyses, this association remained relatively stable. Conclusion: The "L"-shaped association between BRI and mortality indicates that BRI may serve as a useful indicator for evaluating mortality risk in patients with OP, thereby informing clinical interventions and public health approaches.

    Keywords: Body Roundness Index (BRI), Bone Mineral Density (BMD), Osteoporosis, NHANES, All-cause mortality

    Received: 03 Dec 2024; Accepted: 07 Jan 2025.

    Copyright: © 2025 Ding, Li, Qi, Fang, Zhu, Qu, Chen, Sun and Pang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Qirui Zhu, Xuzhou Medical University, Xuzhou, China
    Xinzhe Qu, Xuzhou Medical University, Xuzhou, China
    changchang Chen, Xuzhou Medical University, Xuzhou, China
    Jun Sun, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province, China
    Yong Pang, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.