ORIGINAL RESEARCH article
Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1538133
This article is part of the Research TopicDiet and Digestive Tract Cancers: Investigating the Nutritional Influences on Gastrointestinal CarcinogenesisView all 8 articles
Exploration of the Relationship Between Gastric Cancer and Nutritional Risk Factors: Insights from the Korea National Health Insurance Database
Provisionally accepted
- 1Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Republic of Korea
- 2Ewha Womans University, Seoul, Seoul, Republic of Korea
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Background/Objectives: Gastric cancer is the third most common cause of cancer-related deaths. Gastric cancer rates vary across regions, which may be attributable to factors such as Helicobacter pylori infection, environmental factors, and genetic predispositions. We examined the association between gastric cancer, nutrient intake, and lifestyle parameters in Korean adults. Methods: This study utilized the KNHANES dataset (2012)(2013)(2014)(2015)(2016) to explore the nutritional risk factors associated with gastric cancer. Multivariable analysis was conducted to confirm the association between micronutrients and specific food items using questionnaires designed to collect data on individuals' consumption frequency and nutrient intake. Results: This study enrolled 18,894 participants, including 229 diagnosed with gastric cancer. Factors associated with gastric cancer included male sex, older age, low body-mass index, and frequent consumption of food outside the home. Multivariate analysis indicated that a lower intake of protein (odds ratio [OR] 0.98, 95% confidence interval [CI] 0.97-0.99, p<0.001), fat (OR 0.99, 95% CI 0.98-0.99, p<0.004), and thiamine (OR 0.59, 95% CI 0.45-0.76, p<0.001) and a higher intake of niacin (OR 1.05, 95% CI 1.02-1.08, p<0.001) were correlated with an increased risk of gastric cancer. Additionally, specific dietary items, such as tteok (rice cake) and soju, contributed to an elevated gastric cancer risk (OR 1.21, 95% CI, OR 1.14, 95% CI, p<0.001). Conclusions: We found an association between gastric cancer and various nutritional and lifestyle parameters. Nutrient intake and lifestylerelated factors significantly influence the prevalence of gastric cancer, suggesting that tailored interventions could mitigate this risk in specific populations.
Keywords: gastric cancer, Nutrients, Micronutrients, Food, lifestyle
Received: 02 Dec 2024; Accepted: 15 Apr 2025.
Copyright: © 2025 Kim and Kim. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chi Young Kim, Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Republic of Korea
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