ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition, Psychology and Brain Health
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1537644
This article is part of the Research TopicImplementing Mental Health Prevention and Promotion Programs: A Sustainable Approach - Volume IIView all 7 articles
Fasting blood glucose mediated the association between a body shape index and depression: a cross sectional study from NHANES 2017-2023
Provisionally accepted
- The Affiliated People’s Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
The objective was to evaluate ABSI's association with depression and explore FBG as a possible mediating factor. Methods Data from 8,748 NHANES participants (2017-2023) were analyzed. Logistic regression analyses assessed ABSI-depression associations, while mediation models tested FBG's intermediary role.We conducted stratified analyses and interaction test to assess the impact of gender, age, race, PIR, education, alcohol use, current smoking status, BMI, hypertension history and hypercholesterolemia history on the study outcomes.The fully adjusted logistic regression models demonstrated a significant positiv e association between ABSI and depression(OR=1.20,95%CI:1.00,1.44,P=0.0497). Stratif ied analyses and interaction test showed that this association was significant only amo ng participants with some college education or above (P for interaction < 0.05). No si gnificant interactions were found across other subgroups. Mediation analyses revealed t hat FBG partially mediated the relationship between ABSI and depression(15.8%,P<0.0 001). Conclusion ABSI was associated with depression, potentially mediated through FBG.
Keywords: A Body Shape Index, Depression, Fasting blood glucose, mediation effect, Cross sectional study
Received: 24 Dec 2024; Accepted: 23 Apr 2025.
Copyright: © 2025 Chen, Wei, Wang, Xie, Wang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jing Wang, The Affiliated People’s Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.