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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1534535
This article is part of the Research Topic Dietary Strategies for Managing Hypertension and Hypotension: Insights and Mechanisms View all 9 articles

Interactive Effect between Selenium and Vitamin C Levels on Risk of Hypertension among Adult Women in the United States: Evidence from NHANES 2011 to 2020

Provisionally accepted
Dongfang Wu Dongfang Wu *Ping Fan Ping Fan Julia Ching Julia Ching
  • Global Health Research Center, Duke Kunshan University, Kunshan, Jiangsu, China

The final, formatted version of the article will be published soon.

    Hypertension poses an imperative global health risk, affecting over 1 billion people and contributing to cardiovascular disease, especially for women. While previous studies suggest micronutrients such as Vitamin C or Selenium can help reduce blood pressure, research on their interactive effects remains limited.This cross-sectional study analyzed data from 9,343 women aged 20 years and older in NHANES (2011-2020). Logistic regression analysis was conducted to evaluate the effect of each micronutrient on hypertension. To account for potential interactions between micronutrients, we calculated the relative excess risk, which assesses their combined effect on hypertension.We confirmed the individual associations of Vitamin C and Selenium with hypertension, showing significant negative correlations (p<0.05). Participants were then divided into four groups, and those with high intakes of both Vitamin C and Selenium had a significantly lower risk of hypertension (p<0.05), supporting the association between their combined intake and lower hypertension risk.The findings support the combined intake of Vitamin C and Selenium in hypertension prevention, broadening thoughts on the level of nutrition for the treatment of hypertension. These results suggest a potential association between adequate supplementation of Vitamin C and Selenium and lower blood pressure. However, further rigorous clinical studies are essential to validate and strengthen these findings.

    Keywords: Selenium, vitamin C, Hypertension, Women, NHANES

    Received: 27 Nov 2024; Accepted: 09 Jan 2025.

    Copyright: © 2025 Wu, Fan and Ching. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Dongfang Wu, Global Health Research Center, Duke Kunshan University, Kunshan, Jiangsu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.