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ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition and Metabolism
Volume 12 - 2025 |
doi: 10.3389/fnut.2025.1534336
This article is part of the Research Topic Preventative Medicine: Nutritional and Lifestyle Interventions for Healthy Ageing and Chronic Diseases View all 34 articles
The association between oxidative balance score and gallstones in adults: a populationbased study Author information
Provisionally accepted- 1 Peking University, Beijing, Beijing Municipality, China
- 2 The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China
- 3 Beijing University of Chinese Medicine, Beijing, Beijing Municipality, China
- 4 Peking Union Medical College Graduate School, Beijing, China
- 5 Department of Rheumatology, China-Japan Friendship Hospital, Beijing, China
Oxidative stress is a significant contributor to the progression of gallstones. However, the combined or independent effects of dietary and lifestyle pro-antioxidants and antioxidants on gallstone formation remain unclear. Our study aims to investigate the potential link between the Oxidative Balance Score (OBS) and the occurrence of gallstones.This study utilized data from the National Health and Nutrition Examination Survey (NHANES), conducted in the United States between 2017 and March 2020, identifying 750 gallstone cases among the 7,489 participants. Gallstone status was self-reported. The data in this study were analyzed using a range of statistical techniques, such as Multivariable logistic regression, restricted cubic spline curves (RCS), mediation effects analysis, subgroup analyses and sensitivity analysis.Using fully adjusted Multivariable logistic regression analysis, we identified a significant negative correlation between OBS and the occurrence of gallstones, with an odds ratio (OR) of 0.97 and a 95% confidence interval (CI) of 0.96 to 0.99. Furthermore, participants in the highest quartile of OBS exhibited a 41% reduced risk of gallstones compared to those in the lowest quartile, with an OR of 0.59 (95% CI: 0.45, 0.79) relative to the reference population.Additionally, a linear inverse association between OBS and gallstones was observed.Mediation analysis indicated that diabetes and cardiovascular diseases (CVD) mediated 3.5% and 4% of the association between OBS and gallstones, respectively.This research suggests that lower OBS levels are associated with a higher susceptibility to gallstone formation, potentially offering a new perspective on clinical strategies for the management and prevention of gallstones.
Keywords: BMI, body mass index, CVD, Cardiovascular Diseases, 95% CI, 95% confidence interval, MUFA, monounsaturated fatty acids, NHANES, National Health and Nutrition Examination survey, OBS, oxidative balance score, OR, odds ratio, RCS, restricted cubic spline curves
Received: 25 Nov 2024; Accepted: 05 Feb 2025.
Copyright: © 2025 Yuxiao, Wang, Liu, Yu, Chen and Du. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shiyu Du, Department of Rheumatology, China-Japan Friendship Hospital, Beijing, China
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