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ORIGINAL RESEARCH article
Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1533636
The association between neutrophil percentage-to-albumin ratio (NPAR)
Provisionally accepted- 1Department of Breast and Thyroid Surgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
- 2The Second Clinical College of Fujian Medical University, quanzhou, China
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Background: An increasing amount of research suggests an association between systemic inflammation, nutritional status, and cancer. However, the relationship between the prevalence of breast cancer and neutrophil percentage to albumin ratio (NPAR), a recently identified biomarker of inflammation, is not completely clear. The study aims to investigate the relationship between BC risk and NPAR levels. Methods: This study included 18726 participants from the National Health and Nutrition Examination Survey (NHANES) conducted from 2001 to 2018. Neutrophil percentage to albumin ratio (NPAR) was used to assess inflammation and nutritional status. Statistical methods including multivariate logistic regression, subgroup analysis, and restricted cubic spline analysis were used to explore the influence of NPAR on BC prevalence. Propensity score matching was used to validate the findings further.The prevalence of breast cancer has a significant association with NPAR levels, based on the logistic results (OR=1.05; 95% CI=1.02-1.09, P=0.003). In comparison to the lowest quartile, Q1, the prevalence of breast cancer increased by 5% (P = 0.745), 3% (P = 0.032), and 38% (P = 0.018) for participants in Q2, Q3, and Q4 with higher NPAR levels. NPAR and BC prevalence were positively correlated by subgroup and Restricted Cubic Spline(RCS) analyses. NPAR and marital status interacted with one another.The significance of traits assessed by Mean Decrease Accuracy (MDA) and Mean Decrease Impurity (MDI) was demonstrated using random forest modeling, and NPAR was one of the main variables affecting the occurrence of BC. Furthermore, the linear analysis demonstrated a correlation between high NPAR and elevated Total Testosterone (TT) and Sex Hormone-BindingThere is a significant association between elevated NPAR levels and a higher prevalence of breast cancer, which could be attributed to sex hormone levels. It has been suggested that NPAP may serve as a biomarker for breast cancer in American adult women.
Keywords: NHANES, Inflammation, nutrition, breast cancer, NPAR
Received: 25 Nov 2024; Accepted: 08 Apr 2025.
Copyright: © 2025 Liang, Pan, Wang and Lin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jianqing Lin, Department of Breast and Thyroid Surgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
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