Skip to main content

ORIGINAL RESEARCH article

Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1528114

Association between oxidative balance score and glaucoma in the National Health and Nutrition Examination Survey

Provisionally accepted
Jun Huang Jun Huang Yulan Zhang Yulan Zhang Chao Wu Chao Wu Yifan Wu Yifan Wu Feiran Wang Feiran Wang Yunxuan Ning Yunxuan Ning Lu Shi Lu Shi *
  • Second Affiliated Hospital of Nanchang University, Nanchang, China

The final, formatted version of the article will be published soon.

    Objective: To investigate the association between Oxidative Balance Score (OBS) and glaucoma risk.Methods: Using data from the National Health and Nutrition Examination Survey (2005)(2006)(2007)(2008), we analyzed 2615 participants aged ≥40 years. OBS was calculated from 15 antioxidant and 5 pro-oxidant components, including dietary nutrients and lifestyle factors. Glaucoma was identified through self-reported diagnosis and retinal imaging. Survey-weighted logistic regression and restricted cubic splines (RCS) were used to assess associations.Higher OBS was associated with lower glaucoma risk (adjusted OR=0.97, 95% CI: 0.94-1.00). Participants in the highest OBS quartile showed 51% lower odds of glaucoma compared to the lowest quartile (adjusted OR=0.49, 95% CI: 0.27-0.90).The protective effect was more pronounced among middle-aged adults (40-60 years; OR=0.90, 95% CI: 0.86-0.95) and males (OR=0.93, 95% CI: 0.90-0.97).Higher OBS were associated with lower glaucoma prevalence, particularly among middle-aged adults and males, suggesting potential benefits of maintaining oxidative balance in glaucoma prevention.

    Keywords: Oxidative balance score, Glaucoma, Oxidative Stress, national Health and Nutrition Examination Survey (NHANES), Comprehensive Index

    Received: 14 Nov 2024; Accepted: 03 Jan 2025.

    Copyright: © 2025 Huang, Zhang, Wu, Wu, Wang, Ning and Shi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Lu Shi, Second Affiliated Hospital of Nanchang University, Nanchang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.