The correlation between TyG-BMI and the risk of osteoporosis in middle-aged and elderly patients with type 2 diabetes mellitus

Yanrong Chen Yindi Zhang Si Qin Yu Fadong Yinxing Ni Jian Zhong ^*

• Department of Endocrinology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China

Background and objectives: Osteoporosis (OP) has emerged as one of the most rapidly escalating complications associated with diabetes mellitus. However, the potential risk factors contributing to OP in patients with type 2 diabetes mellitus (T2DM) remain controversial. The aim of this study was to explore the relationship between triglyceride glucose-body mass index (TyG-BMI), a marker of insulin resistance calculated as Ln [triglyceride (TG, mg/dL)×fasting plasma glucose (mg/dL)/2]×BMI，and the risk of OP in T2DM patients.This retrospective cross-sectional study enrolled 386 inpatients with T2DM, comprising both male and postmenopausal female participants aged 40 years or older. Individuals with significant medical histories or medications known to influence bone mineral density were excluded. Machine learning algorithms were employed to rank factors affecting OP risk. Logistic regression analysis was performed to identify independent influencing factors for OP, while subgroup analysis was conducted to evaluate the impact of TyG-BMI on OP across different subgroups. Restricted cubic spline (RCS) analysis was used to explore the dose-response relationship between TyG-BMI and OP. Additionally, the receiver operating characteristic (ROC) curve was utilized to assess the predictive efficiency of TyG-BMI for OP.Results: Machine learning analysis identified TyG-BMI as the strongest predictor for type 2 diabetic osteoporosis in middle-aged and elderly patients. After adjusting for confounding factors, multivariate logistic regression analysis revealed that age, osteocalcin, and uric acid were independent influencing factors for OP. Notably, TyG-BMI also emerged as an independent risk factor for OP (95%CI 1.031-1.054, P < 0.01). Subgroup analysis demonstrated a consistent increase in OP risk with higher TyG-BMI levels across all subgroups. RCS analysis indicated a threshold effect, with the risk of OP gradually increasing when TyG-BMI exceeded 191.52. Gender-specific analysis showed increasing the risk of OP when TyG-BMI surpassed 186.21 in males and 198.46 in females, with a more pronounced trend observed in females. ROC suggested that TyG-BMI index has significant discriminative power for type 2 diabetic osteoporosis.TyG-BMI has been identified as a robust predictive biomarker for assessing OP risk in middle-aged and elderly populations with T2DM.