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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1521882
This article is part of the Research Topic Eating Behavior and Chronic Diseases: Research Evidence from Population Studies, Volume II View all 6 articles

Higher Levels of Oxidative Balance Score Linked to Lower Risk of Gallstones: Findings from the 2017-2020 National Health and Nutrition Examination Survey (NHANES)

Provisionally accepted
Ting Xiong Ting Xiong Zhonghuo Chen Zhonghuo Chen Jianwei Yi Jianwei Yi Taozhi Yu Taozhi Yu Kai Wang Kai Wang *
  • Hepatobiliary and Pancreatic Surgery Division, Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China

The final, formatted version of the article will be published soon.

    Background and Objective: The Oxidative Balance Score (OBS) has been linked to various chronic diseases; however, its association with gallstone prevalence remains underexplored. This study aimed to investigate the relationship between OBS and gallstone risk.Methods: This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) conducted from 2017 to March 2020. Weighted logistic regression models were applied to examine the association between OBS and the prevalence of gallstones, complemented by subgroup and sensitivity analyses. Restricted cubic spline (RCS) was used to investigate the nonlinear association between OBS and the prevalence of gallstones.Results: A total of 5,382 participants were included, among whom 592 reported a history of gallstones. After adjusting for confounding factors, a significant negative association was observed between OBS and gallstone prevalence (quartile 4 vs. quartile 1: odds ratio [OR] 0.63, 95% confidence interval [CI] 0.43-0.90, P = 0.019). The RCS analysis further supported a negative linear relationship between OBS and gallstone risk (nonlinear P = 0.149). The findings of the subgroup analyses exhibited considerable consistency.Conclusion: This study identified a significant negative linear association between OBS and gallstone risk, suggesting that higher OBS levels are associated with a reduced likelihood of gallstone formation.

    Keywords: Oxidative balance score, gallstone, NHANES, Retrospective study, Cross-sectional study

    Received: 03 Nov 2024; Accepted: 10 Jan 2025.

    Copyright: © 2025 Xiong, Chen, Yi, Yu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Kai Wang, Hepatobiliary and Pancreatic Surgery Division, Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.