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REVIEW article
Front. Nutr.
Sec. Nutrition and Microbes
Volume 12 - 2025 |
doi: 10.3389/fnut.2025.1519974
This article is part of the Research Topic Xenobiotics, Gut Microbiota, and Chronic Disease View all 7 articles
Unraveling the Microbial Mysteries: Gut Microbiota's Role in Ulcerative Colitis
Provisionally accepted- The Affiliated Hospital of Qingdao University, Qingdao, China
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by persistent inflammation of the colon. Recent research has highlighted the significant role of gut microbiota in the pathogenesis and treatment of UC. This review aims to provide a comprehensive overview of the current understanding of the relationship between gut microbiota and UC. We discuss the involvement of gut microbiota in the onset of UC, including the dysbiosis observed in patients and its potential mechanisms.Additionally, the role of extra-intestinal microbiota in UC pathogenesis is explored, which has been less studied but is gaining attention. The influence of gut microbiota on the efficacy of biological immunotherapy for UC is also examined, highlighting how microbial composition can influence treatment outcomes. Furthermore, we review microbiota transplantation, and their potential benefits in UC management. Finally, we consider the combined use of antibiotics and biological agents in UC treatment, discussing their synergistic effects and potential drawbacks. This review underscores the importance of gut microbiota in UC and suggests that targeting microbial communities could offer new avenues for effective treatment.
Keywords: ulcerative colitis, Gut Microbiota, Extraintestinal Homeostasis", Biological immunotherapy, fecal microbiota transplantation
Received: 30 Oct 2024; Accepted: 27 Jan 2025.
Copyright: © 2025 Ren, Yong, Jin, Rong, Xue, Cao and Wei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hongyun Wei, The Affiliated Hospital of Qingdao University, Qingdao, China
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