Association between advanced lung cancer inflammation index and acute gouty arthritis in Dalian, China: a cross-sectional study

Ziran Xiu ^1,2 Zhengnan Gao ^1* Lan Luo ^1*

• ¹ Affiliated Central Hospital of Dalian University of Technology, Dalian, China
• ² Graduate School of Dalian Medical University, Dalian, Liaoning Province, China

Introduction: Acute gouty arthritis (AGA) is an inflammatory joint disease. The advanced lung cancer inflammation index (ALI) evaluates inflammation. This study investigates the association between ALI and AGA. Methods: We included 652 participants in this cohort study, dividing them into two groups: those with AGA and a control group without AGA. We employed logistic regression to examine the ALI-AGA relationship, using restricted cubic splines (RCS) to assess dose-response relationships, performing subgroup analyses, and conducting interaction tests. K-fold cross-validation was applied for model assessment. Receiver operating characteristic (ROC) curves were applied to visualize and compare the predictive value of ALI and other inflammatory indices for AGA. Results: Among the 652 participants, the AGA group exhibited significantly lower ALI values compared to the control group. Multivariate logistic regression identified an inverse relationship between ALI and AGA. RCS analysis indicated an L-shaped nonlinear relationship between ALI levels and AGA, with inflection points at an ALI of 23.38. Subgroup analyses showed no significant interactions between ALI levels and AGA after stratifying by age, hypertension, coronary heart disease (CHD), and diabetes (DM). The results from the ROC curves indicate that ALI may serve as a better predictor of AGA.This cross-sectional study found a significant inverse correlation between ALI levels and AGA prevalence. Moreover, the ALI could serve as a more accurate diagnostic tool for AGA and offer a novel approach for further investigating the relationship between inflammation and AGA.