Skip to main content

ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutritional Epidemiology
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1508774
This article is part of the Research Topic Objective Dietary Assessment in Nutrition Epidemiology Studies - Volume II View all 17 articles

Association Between Hyperuricemia and Dietary Retinol Intake in Southwest China: A Cross-Sectional Study Based on CHNS Database

Provisionally accepted
Yi Liang Yi Liang 1Tian Qiao Tian Qiao 1Xiaorong Ni Xiaorong Ni 2Lihui Yang Lihui Yang 1*Tianhua Yao Tianhua Yao 2*Yiya Liu Yiya Liu 3*
  • 1 Department of Clinical Nutrition, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China
  • 2 School of Public Health, Key Laboratory of Environmental Pollution Monitoring and Disease Control, Guizhou Medical University, Guiyang, Guizhou Province, China
  • 3 Nutrition Institute, Guizhou Centre for Disease Control and Prevention, Guiyang, Guizhou Province, China

The final, formatted version of the article will be published soon.

    Background: Hyperuricemia is increasingly common in Southwestern China and poses significant health risks, including gout and cardiovascular disease. Retinol intake has been hypothesized to affect uric acid levels, but this relationship remains unclear. Methods: Data from 4,658 participants in the China Health and Nutrition Survey (CHNS) from 1991 to 2018 were analyzed. Dietary retinol intake was categorized using quantile-based methods, and hyperuricemia was identified as the primary outcome. Logistic regression models were used to estimate odds ratios and 95% confidence intervals, with analyses stratified by gender. Restricted cubic splines were utilized to evaluate the dose-response relationship. Results: The average age of participants was 40±17.83 years, and 20.29% met the criteria for hyperuricemia. Logistic regression analysis identified a positive association between dietary retinol intake and hyperuricemia, with a more pronounced effect observed in men. The restricted cubic spline analysis revealed that the odds of hyperuricemia increased significantly when dietary retinol intake exceeded 3,538 IU/day for men and 4,504 IU/day for women. Conclusion: High dietary retinol intake is associated with an increased risk of hyperuricemia, with a stronger association observed in males. These findings suggest that dietary retinol intake under recommendation levels might be necessary to prevent hyperuricemia-related adverse health outcomes.

    Keywords: Hyperuricemia, Dietary retinol, cross-sectional design, CHNS, Doseresponse

    Received: 09 Oct 2024; Accepted: 03 Jan 2025.

    Copyright: © 2025 Liang, Qiao, Ni, Yang, Yao and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Lihui Yang, Department of Clinical Nutrition, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China
    Tianhua Yao, School of Public Health, Key Laboratory of Environmental Pollution Monitoring and Disease Control, Guizhou Medical University, Guiyang, 550025, Guizhou Province, China
    Yiya Liu, Nutrition Institute, Guizhou Centre for Disease Control and Prevention, Guiyang, 550004, Guizhou Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.