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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1508381

Analysis of influencing factors of washed microbiota transplantation in treating patients with metabolic syndrome

Provisionally accepted
De-jiang Lin De-jiang Lin Qing-Ting Wu Qing-Ting Wu Dong-Xia Hu Dong-Xia Hu Lin-Gui Huang Lin-Gui Huang Zi-Han Lin Zi-Han Lin Jia-Ting Xu Jia-Ting Xu Xing-Xiang He Xing-Xiang He *Lei Wu Lei Wu *
  • The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China

The final, formatted version of the article will be published soon.

    Background and Aims: Metabolic Syndrome (MS) is a cluster of metabolic abnormalities closely associated with hypertension, diabetes, hyperlipidemia, obesity, etc. Our previous research indicated that fecal microbiota transplantation (FMT) could improve MS, but the factors influencing the efficacy of washed microbiota transplantation (WMT) in treating MS patients remain unclear. The objective of this study is to analyze the influencing factors of WMT in treating MS patients. Methods: The clinical data and influencing factors related to MS patients were collected retrospectively. Not only the changes in body mass index (BMI = weight (kg)/height (m) 2 ), blood glucose, blood lipids, and blood pressure were analyzed, but also the influencing factors of WMT in treating MS patients were carried out based on Logistic Regression. The 16S rRNA gene amplicon sequencing was performed on fecal samples before and after WMT treatment. Results: A total of 210 patients were included, including 68 patients in the WMT group and 142 patients in the drug treatment (DT) group. WMT had a significant improvement and ASCVD downregulation effect on MS patients, and 42.65% of MS patients removed the label of MS after WMT treatment. Independent influencing factors for treating MS patients through WMT include age<60 years old, high smoking index, infection, single donor selection, single-course WMT treatment, and having hypertension, diabetes, or obesity. WMT treated MS patients by maintaining the balance of gut microbiota.Conclusions: WMT has a significant effect in improving MS and downregulating ASCVD risk stratification. The therapeutic effect of WMT on MS patients is closely related to their age, smoking index, infection, chronic disease status, donor type and WMT courses. Therefore, we can improve the efficacy of WMT by reducing independent influencing factors that affect gut microbiota homeostasis.

    Keywords: fecal microbiota transplantation, washed microbiota transplantation, metabolic syndrome, Logistic regression, Influencing factors

    Received: 09 Oct 2024; Accepted: 13 Jan 2025.

    Copyright: © 2025 Lin, Wu, Hu, Huang, Lin, Xu, He and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xing-Xiang He, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China
    Lei Wu, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.