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SYSTEMATIC REVIEW article

Front. Nutr.
Sec. Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1502815
This article is part of the Research Topic Micronutrients and Metabolic Diseases-Volume II View all 10 articles

Evaluating the Effects of Seed Oils on Lipid Profile, Inflammatory and Oxidative Markers, and Glycemic Control of Diabetic and Dyslipidemic Patients: A Systematic Review of Clinical Studies

Provisionally accepted
LUCAS FORNARI LAURINDO LUCAS FORNARI LAURINDO 1*Lívia Fornari Laurindo Lívia Fornari Laurindo 2Victória Dogani Rodrigues Victória Dogani Rodrigues 1Jéssica da Silva Camarinha Oliveira Jéssica da Silva Camarinha Oliveira 1Beatriz Leme Boaro Beatriz Leme Boaro 1Adriano Cressoni Araújo Adriano Cressoni Araújo 3Elen Landgraf Guiguer Elen Landgraf Guiguer 3Claudia Rucco Penteado Detregiachi Claudia Rucco Penteado Detregiachi 3Virgínia Maria Cavallari Strozze Catharin Virgínia Maria Cavallari Strozze Catharin 3Eduardo Federighi Baisi Chagas Eduardo Federighi Baisi Chagas 3Vitor Cavallari Strozze Catharin Vitor Cavallari Strozze Catharin 3Rosa Direito Rosa Direito 4Sandra Barbalho Sandra Barbalho 3
  • 1 Medical School of Marilia, Marília, Brazil
  • 2 Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, Brazil
  • 3 Universidade de Marília, Marilia, Sao Paulo, Brazil
  • 4 Research Institute for Medicines (iMed.ULisboa), Lisboa, Lisboa, Portugal

The final, formatted version of the article will be published soon.

    Diabetes mellitus and dyslipidemia are significant health concerns that elevate the risk of cardiovascular disease and other metabolic disorders, necessitating effective management strategies.Recent research has highlighted the potential role of dietary fats, particularly seed oils, in influencing health outcomes in these conditions. This systematic review evaluates the impact of seed oils on lipid profiles, inflammatory and oxidative markers, and glycemic control in patients with diabetes and dyslipidemia. A comprehensive search across databases, including PubMed, Scopus, Web of Science, Cochrane Library, and Google Scholar, identified studies focusing on the effects of seed oils. The studies include randomized controlled, parallel-design, double-blind, placebo-controlled, and openlabel studies published in English. The quality of the studies was assessed through a detailed review process, and data were extracted to evaluate the effects of seed oils on key metabolic markers. The review included 11 studies demonstrating that seed oils derived from canola, flaxseed, and sesame seeds can positively influence lipid profiles and glycemic control while potentially modulating oxidative stress markers. The findings suggest that seed oils may benefit in managing diabetes and dyslipidemia, although the results are sometimes inconsistent. This review provides valuable insights for dietary recommendations and therapeutic strategies, highlighting the need for further research to clarify the role of seed oils in metabolic health.

    Keywords: Seed oils, Dyslipidemia, type 2 diabetes, Lipid profiles, Inflammatory markers, glycemic control, clinical trials, Cardiometabolic Health

    Received: 27 Sep 2024; Accepted: 13 Jan 2025.

    Copyright: © 2025 FORNARI LAURINDO, Fornari Laurindo, Dogani Rodrigues, da Silva Camarinha Oliveira, Leme Boaro, Cressoni Araújo, Landgraf Guiguer, Rucco Penteado Detregiachi, Maria Cavallari Strozze Catharin, Federighi Baisi Chagas, Cavallari Strozze Catharin, Direito and Barbalho. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: LUCAS FORNARI LAURINDO, Medical School of Marilia, Marília, Brazil

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.