The final, formatted version of the article will be published soon.
SYSTEMATIC REVIEW article
Front. Nutr.
Sec. Nutrition and Microbes
Volume 12 - 2025 |
doi: 10.3389/fnut.2025.1502720
This article is part of the Research Topic Nutraceuticals and Functional Foods in Chronic Disease Prevention and Treatment View all 4 articles
Cranberry-Derived Bioactives for the Prevention and Treatment of Urinary Tract Infections: Antimicrobial Mechanisms and Global Research Trends in Nutraceutical Applications
Provisionally accepted- 1 Lovely Professional University, Phagwara, Punjab, India
- 2 National Medical College, Birgunj, Nepal
This review consolidates existing evidence on the efficacy of cranberry-derived bioactive compounds, particularly metabolites like proanthocyanidins (PACs), in preventing urinary tract infections (UTIs). Cranberries offer a promising non-antibiotic strategy for addressing UTIs, a global health concern exacerbated by rising antibiotic resistance. Key cranberry metabolites, including A-type PACs, flavonoids, and phenolic acids, play a critical role in inhibiting Escherichia coli adhesion to uroepithelial cells, reducing UTI recurrence by up to 50%. Gut microbiota-driven conversion of PACs into bioactive metabolites such as valerolactones significantly enhances their biological activity, further highlighting the importance of metabolic processes in UTI prevention. Additionally, emerging research has identified cranberry oligosaccharides as effective inhibitors of biofilm formation in highrisk populations. This review also presents a comprehensive bibliometric analysis of publications from 1962 to 2024, revealing a significant rise in scholarly interest post-2000, particularly in the United States. Collaboration patterns, thematic mapping, and co-authorship networks are explored, highlighting the evolving research landscape around cranberry-based UTI interventions. The review underscores the need for standardized cranberry products and targeted research on dosage optimization and clinical applications to maximize therapeutic efficacy.
Keywords: Nutraceuticals, Functional Foods, cranberry, Metabolites, Urinary Tract Infections, Proanthocyanidins, bibliometric analysis, bioactive compounds
Received: 27 Sep 2024; Accepted: 03 Feb 2025.
Copyright: © 2025 Jangid, Shidiki and Kumar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Amrullah Shidiki, National Medical College, Birgunj, Nepal
Gaurav Kumar, Lovely Professional University, Phagwara, 144411, Punjab, India
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.