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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1489934
This article is part of the Research Topic Nutrition and Metabolism in Cancer: Role in Prevention and Prognosis View all 28 articles

Pre-treatment nutrition-related indicators and the prognosis of patients with newly-diagnosed epithelial ovarian cancer: an ambispective cohort study

Provisionally accepted
Shirui Wang Shirui Wang 1Jingyu Zhu Jingyu Zhu 1Ningjuan Wu Ningjuan Wu 1Nannan Wang Nannan Wang 1Xiaohe Dang Xiaohe Dang 1Minyi Zhao Minyi Zhao 1Juan Zhao Juan Zhao 1Ding Ma Ding Ma 2Xiaofeng Yang Xiaofeng Yang 1*
  • 1 Department of Obstetrics and Gynecology, First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, Shaanxi, China
  • 2 Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,, Wuhan, Hubei Province, China

The final, formatted version of the article will be published soon.

    Background: Few studies have explored the link between nutritional status and prognosis in patients with epithelial ovarian cancer (EOC), and existing findings are controversial. Thus, this study aimed to explore the effects of pre-treatment nutrition-related indicators on the prognosis of patients with newly-diagnosed EOC. Methods: In this ambispective cohort study, 1,020 patients with EOC diagnosed by pathology examination were enrolled and followed-up until December 31, 2023. Univariate and multivariable analyses were conducted on nutrition-related indicators, including body mass index (BMI), albumin (ALB), hemoglobin (Hb), diabetes mellitus (DM), and hyperlipidemia, along with clinicopathological characteristics that might affect patients' first-line chemotherapy response, progression-free survival (PFS), and overall survival (OS). Survival curves were created using the Kaplan–Meier method. A Cox proportional hazards model was established to obtain hazard ratios (HRs) and 95% confidence intervals (CIs). Results: The median follow-up duration was 48 months. Compared with patients having normal nutritional indicators, those with hypoalbuminemia had poorer first-line chemotherapy responses. The proportions of those with complete response (CR), partial response (PR), and stable disease or progressive disease (SD/PD) for the ≤30 g/L, 30

    Keywords: epithelial ovarian cancer, nutrition-related indicators, first-line chemotherapy response, Progression-free survival, overall survival

    Received: 02 Sep 2024; Accepted: 03 Jan 2025.

    Copyright: © 2025 Wang, Zhu, Wu, Wang, Dang, Zhao, Zhao, Ma and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xiaofeng Yang, Department of Obstetrics and Gynecology, First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, 710061, Shaanxi, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.