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REVIEW article
Front. Nutr.
Sec. Nutritional Immunology
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1476622
This article is part of the Research Topic Micronutrients, Immunity and Infection View all 27 articles
Low Vitamin K Status Is a Potential Risk Factor for COVID-19 Infected Patients: a systematic review and meta-analysis
Provisionally accepted- Second Hospital of Hebei Medical University, Shijiazhuang, China
Objective: To provide further data support for the treatment of COVID-19 by conducting a comprehensive analysis of reports on dephosphorylated-uncarboxylated Matrix Gla Protein (dp-ucMGP), which detects the functional vitamin K status post COVID-19 infection, using meta-analysis.Methods: This study conducted a comprehensive review and analysis of relevant research on dp-ucMGP detection in patients infected with COVID-19 through meta-analysis. The article collection period ranged from January 2024 to April 2024. Results: A total of 6 articles were included in this study. Baseline data analysis showed that the age of patients in the COVID-19 infected group was greater than that of the non-infected control group (P=0.030); similarly, the age of patients in the severe infection group was also greater than that of the mild infection group (P=0.003). In the analysis of underlying diseases, statistical differences were found between the Severe group and Mild group in the presence of CVD (P=0.010). A total of 5 studies conducted dp-ucMGP detection in both the COVID-19 infected group and the control group. The results showed that the expression of dp-ucMGP was higher in the infected group than in the control group (P<0.001). Subgroup analysis revealed that the expression of dp-ucMGP in the severe infection group was also higher than that in the mild infection group (P<0.001).Conclusion: COVID-19 infected patients exhibit Low Vitamin K Status, which correlates positively with the severity of infection. Supplementation of vitamin K during COVID-19 infection may potentially mitigate the progression towards severe infection, necessitating further support from clinical data.
Keywords: COVID-19, Low Vitamin K Status, dephosphorylated-uncarboxylated Matrix Gla Protein, Meta-analysis, dp-ucMGP
Received: 08 Aug 2024; Accepted: 10 Feb 2025.
Copyright: © 2025 Liu, Liu, Kang and Yuan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xin Liu, Second Hospital of Hebei Medical University, Shijiazhuang, China
Shiwei Kang, Second Hospital of Hebei Medical University, Shijiazhuang, China
Yadong Yuan, Second Hospital of Hebei Medical University, Shijiazhuang, China
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