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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1446265

Dynamic Skeletal Muscle Loss and Its Predictive Role on 90-day Mortality in Patients with Acute on Chronic Liver Failure

Provisionally accepted
Nan Geng Nan Geng 1Ming Kong Ming Kong 2Jiateng Zhang Jiateng Zhang 2Manman Xu Manman Xu 2Huina Chen Huina Chen 2Wenyan Song Wenyan Song 2Yu Chen Yu Chen 2*Zhongping Duan Zhongping Duan 2*
  • 1 Nanjing Drum Tower Hospital, Nanjing, Jiangsu Province, China
  • 2 Capital Medical University, Beijing, China

The final, formatted version of the article will be published soon.

    Low skeletal muscle mass is an independent risk factor for increased mortality in patients with acute-on-chronic liver failure (ACLF). However, no study has evaluated the temporal changes in muscle mass during the course of ACLF. Therefore, this study aimed to investigate the dynamic changes in muscle mass and their prognostic role in patients with ACLF.A retrospective analysis was conducted on consecutive patients with ACLF who underwent two or more abdominal computed tomography examinations within 90 days of admission. The percentage change rates of the skeletal muscle index at the third lumbar vertebra (L3-SMI) were calculated as (L3-SMIfinal -L3-SMIinitial)/(L3-SMIinitial) × 100.A total of 154 patients with ACLF were included. During the course of ACLF, the

    Keywords: Acute-on-chronic liver failure, Skeletal muscle loss, Sarcopenia, Malnutrition, Shortterm outcome

    Received: 09 Jun 2024; Accepted: 06 Feb 2025.

    Copyright: © 2025 Geng, Kong, Zhang, Xu, Chen, Song, Chen and Duan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yu Chen, Capital Medical University, Beijing, China
    Zhongping Duan, Capital Medical University, Beijing, China

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