Skip to main content

ORIGINAL RESEARCH article

Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1443243

Clinical analysis of risk factors for diarrhea caused by enteral nutrition in patients after craniocerebral surgery

Provisionally accepted
Lei Zhang Lei Zhang Lulu Zhang Lulu Zhang Xiaojie Zhu Xiaojie Zhu Leiming Xu Leiming Xu Lin Zhu Lin Zhu Hai Zhou Hai Zhou Shengkai Yang Shengkai Yang *
  • Binhai County People's Hospital, Yancheng, China

The final, formatted version of the article will be published soon.

    Background Patients undergoing craniocerebral surgery for various reasons often require early enteral nutrition (EN) for energy support to improve the neurological prognosis of patients. However, many patients have a complication of EN: diarrhea. This study aims to analyze the clinical risk factors of diarrhea after EN in patients after craniocerebral surgery. Methods The clinical data of patients hospitalized in the department of neurosurgery and neurosurgical intensive care unit of Binhai County People's Hospital from January 2021 to December 2022 were retrospectively collected. The sex, age, liquid preservation, infusion duration, pipeline assessment, heating during infusion, infusion rate, post-infusion rounds and the oral care were compared in diarrhea group and nondiarrhea group. Based on the variables obtained from LASSO regression, multivariate logistic regression was used to analyze the related variables affecting the occurrence of diarrhea, and a nomogram was constructed to predict the probability of diarrhea after EN in patients after craniocerebral surgery.According to the inclusion and exclusion criteria, 141 patients were enrolled in this study, including 50 patients in the diarrhea group and 91 patients in the nondiarrhea group. Among them, age ≥70 years (OR: 2.240; 95% CI 1.110-4.520), no pipeline assessment before EN (OR: 3.807; 95% CI 1.702-7.643), no heating of EN preparations (OR: 3.188; 95% CI 1.853-6.722), no control of normal infusion rate (OR: 1.721; 95% CI 1.136-3.890), no timely post-infusion rounds after EN (OR: 2.260; 95% CI 1.454-5.075), and no oral care during EN were more likely to have diarrhea. Multivariate Logistic regression analysis showed that EN without heating (OR: 2.135; 95% CI 1.716-5.851) and no oral care (OR: 1.125; 95% CI 1.025-1.652) were associated with diarrhea. Finally, two variables were used to establish diagnostic nomogram after craniocerebral postoperative in patients receiving EN with diarrhea, and the AUC value is 0.848 (95% CI 0.778 to 0.918).

    Keywords: Diarrhea, Enteral Nutrition, Brain Injury, Craniocerebral surgery, risk factor, nomogram

    Received: 04 Jun 2024; Accepted: 08 Jan 2025.

    Copyright: © 2025 Zhang, Zhang, Zhu, Xu, Zhu, Zhou and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Shengkai Yang, Binhai County People's Hospital, Yancheng, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.