ORIGINAL RESEARCH article
Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1435805
Abnormal serum phosphorus was associated with the outcome of communityacquired pneumonia patients. Abnormal serum phosphorus and outcome of CAP
Provisionally accepted
- First Hospital of Qinhuangdao, Qinhuangdao, China
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Objective The present study explored the relationship between serum phosphorus and outcome in patients with community-acquired pneumonia (CAP). Methods The study was a retrospective single-center study. The study was conducted on adult patients hospitalized with CAP at The First Hospital of Qinhuangdao City, Hebei Province, China between January 2015 and December 2018. The primary outcome was in-hospital mortality. Subjects were categorized into four groups: the normal serum phosphorus group (0.81~1.45mmol/L), hypophosphatemia group (Grade 1, 0.48~0.80mmol/L), hypophosphatemia group (Grade 2, <0.48mmol/L) and the hyperphosphatemia group (>1.45mmol/L). Results This study enrolled 1936 CAP inpatients. The in-hospital mortalities were 2.5%, 4.4%, 11.1% and 18.0% in patients with normal phosphorus, hypophosphatemia group (Grade 1 and 2) and hyperphosphatemia, respectively. In univariate logistic regression analysis, the in-hospital mortalities of patients with hypophosphatemia (Grade 2) and hyperphosphatemia were 4.892 (95%CI：1.410～16.969，P=0.012) times and 8.572 (95%CI：4.912～14.960，P<0.001) times than patients with normal phosphorus. After adjusted for confounding factors, hypophosphatemia (Grade 2) (OR=3.715, 95%CI: 1.013~13.633, P=0.048) and hyperphosphatemia (OR=5.221, 95%CI: 2.747~9.924, P<0.001) were independent correlative factors of in-hospital mortality. Conclusions Hyperphosphatemia and severe hypophosphatemia on admission were associated with increased in-hospital mortality among CAP inpatients.
Keywords: Serum phosphorus, Community-acquired pneumonia, Outcome, Abnormal serum phosphorus, outcome of CAP
Received: 22 May 2024; Accepted: 15 Apr 2025.
Copyright: © 2025 Wang, Ma, Ma and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Rui Wang, First Hospital of Qinhuangdao, Qinhuangdao, China
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