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ORIGINAL RESEARCH article
Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1433623
This article is part of the Research Topic Allium: Characterization, Bioaccessibility, Bioavailability and Health Potential View all 3 articles
Effect of Fermented Garlic Extract Containing Nitric Oxide on Radial Artery Pulse Waves in Hypertension Patients: A Feasibility Study
Provisionally accepted- 1 Digital Health Research Division, Korea Institute of Oriental Medicine (KIOM), Daejeon, Republic of Korea
- 2 Department of Diagnostics, Department of Korean Medicine, Dong-eui University, Busan, Republic of Korea
- 3 The Medical Research Institute of Hot Spring, Dong-Eui University, Busan, Busan, Republic of Korea
- 4 Department of Korean Medicine, Graduate school, Dong-Eui University, Busan, Busan, Republic of Korea
- 5 DAEYOMEDI Co., Ltd, Ansan-si, Republic of Korea
Background: This study aimed to evaluate the effect of fermented garlic extract (FGE) containing nitric oxide (NO) on arterial pulse waves in hypertension patients using a noninvasive radial artery tonometry device.Materials and Methods: Forty-one participants were recruited for this study investigating changes in arterial pulse wave characteristics following the ingestion of FGE containing NO over a 2-week period. Arterial pulse wave measurements were taken before and 15, 20, and 25 minutes after FGE administration and 2 weeks after the end of the ingestion period.Results: One participant withdrew, and five participants refused to undergo pulse wave measurements. These six participants were excluded, resulting in 35 participants being included for analysis. Fifteen minutes after the administration of FGE with NO, the systolic and diastolic blood pressure (BP) significantly decreased. The radial augmentation index (RAI), width (w), width/time (w/t) ratio, and stroke volume index (SVI) significantly decreased, while the mean pulse width significantly increased. Notably, the RAI, w, w/t ratio, and SVI exhibited a decreasing trend at 15, 20, and 25 minutes compared to the values before the administration of FGE. After 2 weeks of ingestion, no pulse wave variables showed significant changes compared to those before the administration of FGE.Conclusions: The oral administration of low-dose FGE containing NO showed acute positive effects on the wrist artery, including a reduction in BP and an improvement in arterial stiffness. These findings suggest that this study successfully evaluated the effects of FGE containing NO using quantitative and objective pulse parameters as noninvasive indicators.
Keywords: Nitric Oxide, Fermented garlic extract, Pulse wave, Radial Artery, Blood Pressure, Artery stiffness, Hypertension, noninvasive radial artery tonometry device
Received: 16 May 2024; Accepted: 31 Mar 2025.
Copyright: © 2025 Kim, Kim, Kang and Jeon. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
HeeJung Kang, Department of Korean Medicine, Graduate school, Dong-Eui University, Busan, 614-714, Busan, Republic of Korea
Young-Ju Jeon, Digital Health Research Division, Korea Institute of Oriental Medicine (KIOM), Daejeon, Republic of Korea
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