Skip to main content

ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutritional Epidemiology
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1526575
This article is part of the Research Topic Preventative Medicine: Nutritional and Lifestyle Interventions for Healthy Ageing and Chronic Diseases View all 26 articles

Association between serum pyridoxal 5'-phosphate levels and chronic obstructive pulmonary disease: Findings based on NHANES 2005-2010

Provisionally accepted
  • Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China

The final, formatted version of the article will be published soon.

    Objective: Vitamin B6 is involved in regulating a variety of biological reactions in cell metabolism, and possesses antioxidant and anti-inflammatory biological functions.There is currently no research on the correlation between serum PLP levels and chronic obstructive pulmonary disease (COPD) prevalence. This study aims to explore the relationship between serum PLP levels and COPD prevalence. Methods: This cross-sectional study included adult participants with complete data on COPD diagnosis and serum PLP levels from 2005-2010 National Health and Nutrition Examination Survey (NHANES) database. Generalized linear model (GLM) was employed to analyze the association between serum PLP levels and COPD prevalence.The restricted cubic spline (RCS) curve and threshold effect analysis were used to explore the potential non-linear relationship between serum PLP levels and COPD prevalence. Subgroup analysis was carried out to assess the robustness of the relationship between serum PLP levels and COPD prevalence.Results: A total of 11103 participants were included in this study, of whom 830 were diagnosed with COPD. Higher PLP levels are associated with a reduced prevalence of COPD. GLM anaysis confirmed that the groups with higher PLP levels (Q3 and Q4) had a significantly lower prevalence rate of COPD compared to the group of Q2. The RCS curves showed a non-linear "L"-shaped relationship between serum PLP levels and COPD prevalence. The threshld effect analysis found a critical point of 43.3 nmol/L. When serum PLP level is below 43.3nmol/L, there is a negative correlation between serum PLP levels and COPD prevalence (P for overall <0.001, P for nonlinear <0.001). Subgroup analysis and interaction tests confirmed the robustness of the relationship.This study is the first to discover a non-linear relationship between serum PLP levels and COPD prevalence. Higher serum PLP levels are associated with a reduced prevalence of COPD.

    Keywords: COPD, Vitamin B6, serum pyridoxal 5'-phosphate, PLP, NHANES

    Received: 11 Nov 2024; Accepted: 16 Dec 2024.

    Copyright: © 2024 Liu and Yan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yanbin Liu, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China
    Jun Yan, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.