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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutritional Epidemiology
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1521770
This article is part of the Research Topic Exploring the Obesity-Cancer Nexus: Dietary Influences and Biological Mechanisms View all 3 articles

An analysis of the global burden of gallbladder and biliary tract cancer attributable to high BMI in 204 countries and territories:1990-2021

Provisionally accepted
Zhuowen Hu Zhuowen Hu Xue Wang Xue Wang Xin Zhang Xin Zhang Wuping Sun Wuping Sun *Jun Mao Jun Mao *
  • Department of clinical laboratory, Fifth Affiliated Hospital, Southern Medical University, Guangzhou, China

The final, formatted version of the article will be published soon.

    Background: Gallbladder and biliary tract cancers (GBTCs) are aggressive with poor prognosis, often undetected until advanced stages. High Body Mass Index (BMI) is a significant risk factor, contributing substantially to GBTC mortality and Disability-Adjusted Life Years (DALYs). This study aimed to quantify the global burdens of GBTCs attributable to high BMI from 1990 to 2021, thereby developing more rational prevention and treatment strategies for GBTC.Methods: Data were extracted from the Global Burden of Disease (GBD) 2021. Agestandardized rates of mortality (ASMR), and DALYs (ASDR) for GBTCs due to high BMI were calculated by years, genders, ages, geographical locations, and sociodemographic index (SDI). The estimated annual percentage change (EAPC) was calculated to evaluate the temporal trends from 1990 to 2021. Decomposition and frontier analyses were conducted to understand the driving forces behind burden changes and to identify top-performing countries. Inequality analysis was conducted to assess burden disparities across different SDI levels. The disease burden was forecasted through 2035 using the Bayesian age period cohort (BAPC) model.Globally, ASMR and ASDR for GBTCs related to high BMI decreased from 1990 to 2021; however, the absolute number of deaths and DALYs cases more than doubled, and similar patterns are projected to continue over the next 14 years in the absence of intervention. High SDI regions showed higher burdens due to higher obesity rates, population growth, and aging, while low SDI regions faced higher EAPCs due to

    Keywords: Gallbladder and biliary tract cancer, Global burden, High BMI, health inequalities, Mortality

    Received: 02 Nov 2024; Accepted: 04 Dec 2024.

    Copyright: © 2024 Hu, Wang, Zhang, Sun and Mao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Wuping Sun, Department of clinical laboratory, Fifth Affiliated Hospital, Southern Medical University, Guangzhou, China
    Jun Mao, Department of clinical laboratory, Fifth Affiliated Hospital, Southern Medical University, Guangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.