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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutritional Epidemiology
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1519570

Association between oxidative balance score and all-cause, CVD and respiratory-related mortality in the US older adults of asthma patients with diabetes

Provisionally accepted
Chang - Liu Chang - Liu 1*Dan Liang Dan Liang 2Guoan Xiang Guoan Xiang 3Xuanbo Zhao Xuanbo Zhao 4Kun Xiao Kun Xiao 3Lixin Xie Lixin Xie 3
  • 1 Nankai University, Tianjin, China
  • 2 First People's Hospital of Chongqing Liangjiang New District, Chongqing, China
  • 3 People's Liberation Army General Hospital, Beijing, Beijing Municipality, China
  • 4 First Clinical Medical College, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China

The final, formatted version of the article will be published soon.

    This study aims to investigate the correlation between oxidative balance score (OBS) and all-cause, cardiovascular disease (CVD) and respiratory-related mortality within a cohort that includes older asthma patients with diabetes.Data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2001 to 2018, which included 611 participants, were analyzed. Mortality outcomes were determined by linking the data to National Death Index (NDI) records through December 31, 2019. Cox regression modeling was employed to examine the relationship between OBS and all-cause, CVD and respiratory-related mortality. Restricted cubic splines (RCS), subgroup analyses and interaction tests were also conducted in this study.Over a median follow-up of 78.96 months, there were 216 all-cause deaths and 57 CVD-related deaths. A significant negative association was found between the OBS and all-cause and CVD mortality. We did not observe OBS could reduce respiratory-related mortality in older asthma patients with diabetes. RCS analysis indicated a linear and inverse association between the OBS and all-cause and CVD mortality.Subgroup analyses and interaction tests indicated the negative association between OBS and CVD mortality was significantly influenced by alcohol consumption.In this sample, higher OBS was associated with lower all-cause and CVD mortality risks. These findings stressed the importance of infection status in assessing oxidative balance's impact on health.

    Keywords: diabetes, NHANES, All-cause mortality, CVD mortality, OBS

    Received: 14 Nov 2024; Accepted: 23 Dec 2024.

    Copyright: © 2024 Liu, Liang, Xiang, Zhao, Xiao and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Chang - Liu, Nankai University, Tianjin, 300071, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.