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REVIEW article

Front. Nutr.
Sec. Nutrition and Metabolism
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1515806
This article is part of the Research Topic Diet, Trace Elements, and Gut Microbiota in Bone and Cartilage Diseases View all 5 articles

Potential role of gut-related factors in the pathology of cartilage in osteoarthritis

Provisionally accepted
Peng Ning Peng Ning 1*Shuting Lin Shuting Lin 2*Yongyan Shi Yongyan Shi 3*Tianjing Liu Tianjing Liu 2*
  • 1 Department of Pediatric surgery, Shenshan Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Shanwei , China, 516600, Shanwei, China
  • 2 Department of Pediatric Orthopaedics, ShengJing Hospital of China Medical University, Shenyang, China
  • 3 Department of Pediatrics, ShengJing Hospital of China Medical University, Shenyang, Liaoning Province, China

The final, formatted version of the article will be published soon.

    Osteoarthritis (OA) is a common progressive degenerative disease. Gut microbiota (GM) and their metabolites have been closely associated with the onset, progression, and pathology of OA. GM and their metabolites may influence the cartilage directly, or indirectly by affecting the gut, the immune system, and the endocrine system. They function through classical pathways in cartilage metabolism and novel pathways that have recently been discovered. Some of them have been used as targets for the prevention and treatment of OA. The current study sought to describe the major pathological signaling pathways in OA chondrocytes and the potential role of gut-related factors in these pathways.

    Keywords: Osteoarthritis, gut, microbiota, signaling pathway, molecular mechanism

    Received: 23 Oct 2024; Accepted: 19 Dec 2024.

    Copyright: © 2024 Ning, Lin, Shi and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Peng Ning, Department of Pediatric surgery, Shenshan Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Shanwei , China, 516600, Shanwei, China
    Shuting Lin, Department of Pediatric Orthopaedics, ShengJing Hospital of China Medical University, Shenyang, China
    Yongyan Shi, Department of Pediatrics, ShengJing Hospital of China Medical University, Shenyang, Liaoning Province, China
    Tianjing Liu, Department of Pediatric Orthopaedics, ShengJing Hospital of China Medical University, Shenyang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.